Sumipax ODS A色譜柱
通用ODS柱
SUMIPAX ODS A系列是通用ODS柱，具有疏水性端蓋表面結(jié)構(gòu)，易于分離各種化合物。此外，它為堿性化合物和酸性化合物提供了穩(wěn)定的再現(xiàn)性。除了分析藥物、農(nóng)用化學(xué)品、食品和生物物質(zhì)外，還可用于環(huán)境和化學(xué)工業(yè)等各個(gè)領(lǐng)域的高度通用的產(chǎn)品。
產(chǎn)品參數(shù)
SUMIPAX ODS ?粒度（μm）孔徑(?)比表面積（m2/g）孔隙體積（mL/g）碳含量（%）有用的pH范圍 ?金屬雜質(zhì)（ppm）
A series51203001172.5～7.5小于10ppm
應(yīng)用
水溶性維sheng素（B族維sheng素）鼻炎藥物
Sumipax ODS A色譜柱
產(chǎn)品名稱
SUMIPAX ODS? 內(nèi)徑（mm） 長(zhǎng)度（mm）產(chǎn)品代碼
Sumipax ODS ?A-216? ?4*150? ? ?AA216-4015W
Sumipax ODS ?A-217 ? ? ? ? ? ? ? ?4.6*150? ?AA217-4615W
Sumipax ODS ?A-211 ? ? ? ? ? ? ? ?4.6*250? ?AA211-4625W
Sumipax ODS ?A-215 6*100? ? ?AA215-6010W
Sumipax ODS ?A-212 6*150? ? AA212-6015W
Sumipax ODS ?A-214 6*300? ? AA214-6030W
Sumipax ODS ?A-213 10*250? ? AA21310025W
LC-MS型
Sumipax ODS A-210MS? 2*150? ? ?AA210M2015W
溶劑節(jié)省型
Sumipax ODS A-210EC? ?3*150? ? AA210E3015W
SUMICHIRAL OA柱是高效液相色譜法分離對(duì)映體的高效手性柱。在SUMICHIRAL OA柱上可以有效地實(shí)現(xiàn)各種對(duì)映體的直接分離。
對(duì)映體分離是通過(guò)各種非對(duì)映體相互作用實(shí)現(xiàn)的，如氫鍵、電荷轉(zhuǎn)移和主客體相互作用等。SUMICHIRAL OA柱對(duì)于準(zhǔn)確測(cè)定光學(xué)純度和制備生物活性化合物（如藥物、農(nóng)藥和香料）的純對(duì)映體非常有用。
■ 旋轉(zhuǎn)異構(gòu)型
■ 配體交換類型
■ 主客類型
]]>日本住友化學(xué)代理
日本住友化學(xué)官網(wǎng)
歡迎訪問(wèn)日本住友化學(xué)SUMICHIRAL官網(wǎng)或者咨詢我們獲取更多相關(guān)產(chǎn)品信息。
Core-shell type chiral stationary phase
SUMICHIRALTM?OA-SHELL P1
Advantages
SUMICHIRALTM?OA-SHELL P1 is our first chiral stationary phase using optical active polymer. It is effective for chiral separation of compounds without amino group or carboxyl group，which are generally difficult to separate with conventional chiral stationary phases. Especially, it shows excellent resolution for aromatic chiral alcohol compounds. Core‐shell silica is used as a support and coated with poly (diphenylacetylene) derivative (optically active spiral polymer).
【Advantages of SUMICHIRALTM??OA-SHELL P1】
Chiral stationary phase using core-shell silica support
★?Analysis time could be shortened with conventional HPLC ★
- Effective for chiral separation of compounds without amino group or carboxyl group ★
- Easy method development with simple mobile phase compositions ★
- Excellent durability, lot-to-lot repeatability ★
Unlike full porous particles, the core-shell particle has a non-porous core in the center and a thin porous layer outside of the core.
【Method development 】
SUMICHIRALTM?OA-SHELL P1 makes it easy to set the conditions of mobile phase. The scheme of the general method development is shown in the right figure. For neutral compounds such as aromatic alcohols, it is not usually necessary to add special modifiers. For acidic compounds, add trifluoroacetic acid.
- Do not use the following solvents as they will cause the column to deteriorate : tetrahydrofuran, 1,2-dichloroethane, chloroform, ethyl acetate, acetone, etc.
Standard mobile phase n-hexane/2-propanol（95/5）
Change the concentration of 2 -propanol and adjust the retention time
（concentration of 2-propanol 0～20％）
Change 2-propanol to ethanol
（concentration of ethanol 0～10％）
For acidic compounds etc., add trifluoroacetic acid
| 【Durability test】 | （concentration of trifluoroacetic acid | 0.02～0.1％） | |
SUMICHIRALTM?OA-SHELL P1 has excellent durability despite the use of optically active polymers as chiral selectors. The mobile phase was continuously fed to the column, and the stability was evaluated under the following conditions. As a result, almost no change was observed in separation factor, resolution, retention time, and column pressure.
Conditions
mobile phase：n-hexane / ethanol（95/5）
flow rate：0.2 ｍL/min detection：UV254 nm
column temperature：25℃
sample：trans-2-phenyl-1-cyclohexanol 10
Ordering information
【Specification of SUMICHIRALTM?OA-SHELL P1】
| chiral selector | core-shell silica support | ||||
| particle size | pore size | specific surface area | |||
| poly (diphenylacetylene) | 2.6 μm | 250～280? | 40～60 m2/g | ||
| derivative | |||||
| 【List of SUMICHIRALTM?OA-SHELL | P1】 | ||||
| particle size | internal diameter | column length | P/N | ||
| （μｍ） | （mm） | （mm） | |||
| 50 | C-SP01-3005W | ||||
| 2.6 | 3.0 | 100 | C-SP01-3010W | ||
| 150 | C-SP01-3015W | ||||
【List of guard filter】
For column protection, we recommend porous glass guard filter “SUMIPAXTM?Filter PG-ODS for semi-micro “.
| product name | contents | P/N | |||
| SUMIPAXTM?Filter Starter kit PG-ODS | SUS holder | 1 pcs | GMODS001 | ||
| for semi-micro | filter 1 pcs | ||||
| SUMIPAXTM?Filter PG-ODS | replacement filter 8 pcs | GMODS002 | |||
| Replacement filter | for semi-micro | ||||
| SUMIPAXTM??Holder | for semi-micro | SUS holder | 1 pcs | GMACC001 | |
| Connection kit for semi-micro | ferrule screw | 2 pcs | GMACC002 | ||
| SUS tube | 1 pcs | ||||
【Column selection】
There are many kinds of SUMICHIRALTM?series columns, so it is important to select the optimum column depending on the target compounds. Since you can use the database of chiral applications on our website and search application data from compound names and functional group information, please refer to the column selection.
- SUMICHIRALTMand SUMIPAXTM?are registered trademarks in Japan.
- For prices and column sizes other than the above, please contact our distributor.
SUMICHIRAL 選擇選擇方法
- SUMICHIRAL OA-2000 series
- SUMICHIRAL OA-3000 series
- SUMICHIRAL OA-4000 series
- SUMICHIRAL OA-5000 series
- SUMICHIRAL OA-6000 series
- SUMICHIRAL OA-7000 series
- SUMICHIRAL OA-8000 series
- SUMICHIRAL AGP , CBH , HSA
- SUMICHIRAL Columns Product list
SUMICHIRAL OA series is a pioneer of chiral HPLC stationary phase using low molecular weight chiral selector.
SUMICHIRAL OA 系列手性柱是高性能的分離光學(xué)異構(gòu)體的HPLC色譜柱。SUMICHIRAL OA色譜柱能直接分離各種異構(gòu)體，并可從非對(duì)應(yīng)異構(gòu)體中分離異構(gòu)體，這些非對(duì)應(yīng)異構(gòu)體中可能存在氫鍵，電荷轉(zhuǎn)移及主客體等相互作用。OA系列手性柱能精確測(cè)定各種手性化合物的純度，如藥物、農(nóng)藥、香料中手性結(jié)構(gòu)的組成。
OA-2000系列柱，改進(jìn)刷型（Amide），不對(duì)稱碳原子鍵合CONH基團(tuán)
OA-2000系列柱可直接分離芳香類、酯類、羧酸類和醇類化合物的異構(gòu)體。如OA-2000色譜柱分離合成除蟲(chóng)菊酯，OA-2500可分離布洛芬藥物。
OA-3000系列柱，改性刷型（尿素），不對(duì)稱碳原子鍵合NHCONH基團(tuán)
OA-3000系列色譜柱可有效分離羧酸類化合物，尤其是乙?；途郯滨サ陌被峄衔?。OA-3300色譜柱能直接分離布洛芬藥物，乙酰胺基酸，BOC-氨基酸和芐基氨基酸。
OA-4000系列柱，改進(jìn)刷型，胺和氨基酸兩個(gè)手性中心鍵合NHCONH基團(tuán)
OA-4000系列柱通過(guò)電荷轉(zhuǎn)移和氫鍵相互作用達(dá)到手性識(shí)別，能分離各種各樣的化合物，如胺類和氨基醇的藥物，醇類，酯類和酰胺類化合物可用正相模式分離。尤其是酰胺和聚氨酯的衍生物，醇類等柱效高。
OA-5000和OA-6000系列柱在反相模式中通過(guò)配位交換相互作用進(jìn)行手性識(shí)別。OA-5000手性配位體是青霉胺涂敷在ODS硅膠表面，OA-6000手性配位體是酒石酸衍生物涂敷在ODS硅膠表面，限制了添加到流動(dòng)相的有機(jī)溶劑用量，且OA-5000和OA-6000系列柱的流動(dòng)相中必須包含Cu2+離子。該系列柱不但能有效的分離氨基酸，羥基酸的對(duì)映異構(gòu)體，而且能分離銅螯合形成的化合物，如氨基醇，胺，羧酸，氨基內(nèi)酰胺和二肽。尤其是OA-5000柱應(yīng)用極為廣泛，OA-6000能有效分離β-氨基酸，β-羥基酸和親水性阿明酸。
OA-7000柱手性固定相是β-環(huán)糊精通過(guò)新型的空間模式鍵合硅膠?？稍诜聪鄺l件下分離大量的消旋體，包括酮，胺，氨基酸衍生物。
OA-8000柱手性固定相是冠醚手性鍵合氨丙基硅膠，可有效的分離胺，氨基醇和氨基酸的對(duì)映異構(gòu)體，尤其是疏水性胺。
Features
-
Enables direct high quality separation of optical isomers.
Enables direct high quality separation of optical isomers by a large number of theoretical plate.
-
Elution order inversion
In the SUMICHIRAL OA series, low molecular weight optically active compounds are immobilized onto the stationary phase. By immobilizing an antipode of this optically active component, the elution order of the target substance can be reversed. (Excluding OA-4800/4900/7000 series, 8000, AGP, CBH, and HSA)
-
Applicable for LC-MS
SUMICHIRAL OA-2500/3000 series is applicable for LC-MS as the recommended mobile phase is methanol containing ammonium acetate.
-
Supercritical Fluid Chromatography (SFC)
SUMICHIRAL OA-2000 and OA-4000 series are also available for Supercritical fluid chromatography (SFC).
Product lineup
Separation of enantiomers takes place due to the minor energy difference between the solute and the stationary phase caused by diastereomeric interactions (e.g., hydrogen bonding, charge transfer, coordinate bonding).
SUMICHIRAL column types, optically active component, separation mode and target substances are summarized in the table below.
Optical isomers separation columns (low molecular weight isomers)
Amide-type
| SUMICHIRAL | Opticall acitive components | Separation mode | Target substances | Columns for elution order inversion SUMICHIRAL OA |
|---|---|---|---|---|
| OA-2000 | (R)-Phenylglycine | Normal phese | Esters, alcohols, amides, ketones | OA-2000S |
| OA-2000I | Esters, ketones | OA-2000SI | ||
| OA-2500 | (R)-1-Naphtyl glycine | Reversed phese* | Carboxylic acids, alcohols, esters, ketones | OA-2500S |
| OA-2500I | Normal phese | Esters, alcohols, ketones | OA-2500SI |
- Reversed phese* : non-aqueous reversed phase (ammonium acetate/methanol solution)
- Click here for product details, separation examples, and product list of the SUMICHIRAL OA-2000 series.
Urea-type
| SUMICHIRAL | Opticall acitive components | Separation mode | Target substances | Columns for elution order inversion SUMICHIRAL OA |
|---|---|---|---|---|
| OA-3100 | (S)-Valine | Reversed phase* | Carboxylic acids (N-amino acid derivatives) |
OA-3100R |
| OA-3200 | (S)-tert-Leucine | OA-3200R | ||
| OA-3300 | (R)-Phenylglycine | OA-3300S | ||
| OA-4000 | (S)-Valine, (S)-NEA | Normal phese | Amines, amides, aminoalcohols, alcohols, esters, phosphamides | OA-4000R |
| OA-4100 | (S)-Valine, (R)-NEA | OA-4100R | ||
| OA-4400 | (S)-Proline, (S)-NEA | OA-4400R | ||
| OA-4500 | (S)-Proline, (R)-NEA | OA-4500R | ||
| OA-4600 | (S)-tert-Leucine, (S)-NEA |
OA-4600R | ||
| OA-4700 | (S)-tert-Leucine, (R)-NEA |
OA-4700R | ||
| OA-4800 | (S)-Indoline-2-carboxylic acid, (S)-NEA |
— | ||
| OA-4900 | (S)-Indoline-3-carboxylic acid, (R)-NEA |
— |
- Reversed phese* : non-aqueous reversed phase (ammonium acetate/methanol solution)
(S)-NEA ： (S)-1- (α-Naphtyl) ethylamine
(R)-NEA ： (R)-1- (α-Naphtyl) ethylamine
- Click here for product details, separation examples, and product list of the SUMICHIRAL OA-3000 series.
- Click here for product details, separation examples, and product list of the SUMICHIRAL OA-4000 series.
Ligand exchange-type
| SUMICHIRAL | Opticall acitive components | Separation mode | Target substances | Columns for elution order inversion SUMICHIRAL OA |
|---|---|---|---|---|
| OA-5000 | (D)-Penicillamine | Reversed phase | Amino acids, hydroxy acids, amino alcohols, amines | OA-5000L |
| OA-6000 | (L)-Tartaric acid, (R)-NEA |
OA-6000R | ||
| OA-6100 | (L)-Tartaric acid, (S)-Valine, (S)-NEA |
OA-6100R |
- (S)-NEA ： (S)-1- (α-Naphtyl) ethylamine
(R)-NEA ： (R)-1- (α-Naphtyl) ethylamine
- Click here for product details, separation examples, and product list of the SUMICHIRAL OA-5000 series.
- Click here for product details, separation examples, and product list of the SUMICHIRAL OA-6000 series.
Host-guest-type
| SUMICHIRAL | Opticall acitive components | Separation mode | Target substances |
|---|---|---|---|
| OA-7000 | β-Cyclodexitrin | Reversed phase | Flavonoid derivatives, acids, neutral compunds |
| OA-7100 | β-Cyclodexitrin | Acids, neutral compounds | |
| OA-7500 | Methyl-β-cyclodexitrin | Alcohols, esters | |
| OA-7600 | Methyl-α-cyclodexitrin | Neutral compounds | |
| OA-7700 | Acetyl-β-cyclodexitrin | Amines | |
| OA-8000 | Chiral pseudo-crown ether | Normal phase | Primary amines |
| Reversed phase |
- Click here for product details, separation examples, and price table of the SUMICHIRAL OA-7000 series.
- Click here for product details, separation examples, and price table of the SUMICHIRAL OA-8000 series.
Optical isomer separation columns (proteins)
| SUMICHIRAL | Opticall acitive components | Separation mode | Target substances |
|---|---|---|---|
| AGP | α1-acid glycoprotein | Reversed phase | Acids, bases, neutral compounds, amides, ketones |
| CBH | Cellobiohydrolase | Reversed phase | Bases |
| HSA | Human serum albumin | Reversed phase | Acids |
- Click here for product details, separation examples, and prioduct list of the SUMICHIRAL AGP, CBH and HSA.
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日本住友化學(xué)官網(wǎng)
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SUMICHIRAL?選擇選擇方法
- SUMICHIRAL OA-2000 series
- SUMICHIRAL OA-3000 series
- SUMICHIRAL OA-4000 series
- SUMICHIRAL OA-5000 series
- SUMICHIRAL OA-6000 series
- SUMICHIRAL OA-7000 series
- SUMICHIRAL OA-8000 series
- SUMICHIRAL AGP , CBH , HSA
- SUMICHIRAL Columns Product list
製品名
- SUMICHIRAL OA-4000、OA-4100
- SUMICHIRAL OA-4400、OA-4500
- SUMICHIRAL OA-4600、OA-4700
- SUMICHIRAL OA-4800、OA-4900
SUMICHIRAL OA-4000、OA-4100
Features
Used for normal phase systems
Applicable for a wide variety of compounds,such as aromatic amines and amides
Able to inverse the elution order
Supports SFC (supercritical fluid chromatography)
Active site
Product specification
| Product name | SUMICHIRAL OA-4000 | SUMICHIRAL OA-4100 |
|---|---|---|
| Chiral selectors | (S)-Valine， (S)-1-(α-Naphtyl) ethylamine |
(S)-Valine， (R)-1-(α-Naphtyl) ethylamine |
| Support | High purity silica gel | |
| Particle size | 5μm | |
| Supporting mode | Chemically bonded | |
| Recommended mobile phase | Hexane/ethanol/trifluoroacetic acid | |
| Target compounds | Amines, amides, aminoalcohols, alcohols, esters, phosphamides | |
| Columns for elution order inversion | SUMICHIRAL OA-4000R | SUMICHIRAL OA-4100R |
Product list
| Product name | Internal diameter (mm) | Length (mm) | Product code |
|---|---|---|---|
| SUMICHIRAL OA-4000 | 4 | 10 | C-4001-4001W |
| 150 | C-4001-4015W | ||
| 250 | C-4001-4025W | ||
| 4.6 | 50 | C-4001-4605W | |
| 150 | C-4001-4615W | ||
| 250 | C-4001-4625W | ||
| 8 | 250 | C-4001-8025W | |
| 10 | 250 | C-400110025W | |
| 20 | 250 | C-400120025W | |
| SUMICHIRAL OA-4100 | 4 | 10 | C-4101-4001W |
| 150 | C-4101-4015W | ||
| 250 | C-4101-4025W | ||
| 4.6 | 50 | C-4101-4605W | |
| 150 | C-4101-4615W | ||
| 250 | C-4101-4625W | ||
| 8 | 250 | C-4101-8025W | |
| 10 | 250 | C-410110025W | |
| 20 | 250 | C-410120025W |
| Product name | Internal diameter (mm) | Length (mm) | Product code |
|---|---|---|---|
| SUMICHIRAL OA-4000R | 4 | 10 | C-4011-4001W |
| 150 | C-4011-4015W | ||
| 250 | C-4011-4025W | ||
| 4.6 | 50 | C-4011-4605W | |
| 150 | C-4011-4615W | ||
| 250 | C-4011-4625W | ||
| 8 | 250 | C-4011-8025W | |
| 10 | 250 | C-401110025W | |
| 20 | 250 | C-401120025W | |
| SUMICHIRAL OA-4100R | 4 | 10 | C-4111-4001W |
| 150 | C-4111-4015W | ||
| 250 | C-4111-4025W | ||
| 4.6 | 50 | C-4111-4605W | |
| 150 | C-4111-4615W | ||
| 250 | C-4111-4625W | ||
| 8 | 250 | C-4111-8025W | |
| 10 | 250 | C-411110025W | |
| 20 | 250 | C-411120025W |
- ※Note: Those shown in red are standard size for analysis.
Internal diameter of 4 mm and length of 10 mm is a guard column.
SUMIPAX Filter can be used in place of a guard column.
- Click here for SUMIPAX Filters
Applications
SUMICHIRAL OA-4000(5μm, 4.6mm i.d.×250mm)
hexane / 2-propanol (100 : 0.05)
UV 230 nm ｜ 1.0 mL / min ｜ 1μL (1 mg / mL)
SUMICHIRAL OA-4000(5μm, 4.6mm i.d.×250mm)
hexane / ethanol (93 : 7)
UV 254 nm ｜ 1.0 mL / min
SUMICHIRAL OA-4100(5μm, 4.6mm i.d.×250mm)
hexane / 2-propanol / methanol / trifluoroacetic acid (70 : 30 : 0.5 : 0.5)
UV 254 nm ｜ 1.0 mL / min ｜ 5μL (5 mg / mL)
SUMICHIRAL OA-4100(5μm, 4.6mm i.d.×250mm)
hexane / ethanol (98 : 2)
UV 230 nm ｜ 1.0 mL / min ｜ 1μL (1 mg / mL)
- SUMICHIRAL Database
- Guidelines for Selection of SUMICHIRAL Columns
SUMICHIRAL OA-4400、OA-4500
Features
- Used for normal phase systems
- Applicable for a wide variety of compounds, such as aromatic amines and amides
- Able to inverse the elution order
- Supports SFC (supercritical fluid chromatography)
Active site
Product specification
| Product name | SUMICHIRAL OA-4400 | SUMICHIRAL OA-4500 |
|---|---|---|
| Chiral selectors | (S)-Proline， (S)-1-(α-Naphtyl) ethylamin |
(S)-Proline， (R)-1-(α-Naphtyl) ethylamin |
| Support | High purity silica gel | |
| Particle size | 5μm | |
| Supporting mode | Chemically bonded | |
| Recommended mobile phase | Hexane/ethanol/trifluoroacetic acid | |
| Target compounds | Amines, amides, aminoalcohols, esters, phosphamides | |
| Columns for elution order inversion | SUMICHIRAL OA-4400R | SUMICHIRAL OA-4500R |
Product list
| Product name | Internal diameter (mm) | Length (mm) | Product code |
|---|---|---|---|
| SUMICHIRAL OA-4400 | 4 | 10 | C-4401-4001W |
| 150 | C-4401-4015W | ||
| 250 | C-4401-4025W | ||
| 4.6 | 50 | C-4401-4605W | |
| 150 | C-4401-4615W | ||
| 250 | C-4401-4625W | ||
| 8 | 250 | C-4401-8025W | |
| 10 | 250 | C-440110025W | |
| 20 | 250 | C-440120025W | |
| SUMICHIRAL OA-4500 | 4 | 10 | C-4501-4001W |
| 150 | C-4501-4015W | ||
| 250 | C-4501-4025W | ||
| 4.6 | 50 | C-4501-4605W | |
| 150 | C-4501-4615W | ||
| 250 | C-4501-4625W | ||
| 8 | 250 | C-4501-8025W | |
| 10 | 250 | C-450110025W | |
| 20 | 250 | C-450120025W |
| Product name | Internal diameter (mm) | Length (mm) | Product code |
|---|---|---|---|
| SUMICHIRAL OA-4400R | 4 | 10 | C-4411-4001W |
| 150 | C-4411-4015W | ||
| 250 | C-4411-4025W | ||
| 4.6 | 50 | C-4411-4605W | |
| 150 | C-4411-4615W | ||
| 250 | C-4411-4625W | ||
| 8 | 250 | C-4411-8025W | |
| 10 | 250 | C-441110025W | |
| 20 | 250 | C-441120025W | |
| SUMICHIRAL OA-4500R | 4 | 10 | C-4511-4001W |
| 150 | C-4511-4015W | ||
| 250 | C-4511-4025W | ||
| 4.6 | 50 | C-4511-4605W | |
| 150 | C-4511-4615W | ||
| 250 | C-4511-4625W | ||
| 8 | 250 | C-4511-8025W | |
| 10 | 250 | C-451110025W | |
| 20 | 250 | C-451120025W |
- ※Note: Those shown in red are standard size for analysis.
Internal diameter of 4 mm and length of 10 mm is a guard column.
SUMIPAX Filter can be used in place of a guard column.
- Click here for SUMIPAX Filters
Applications
SUMICHIRAL OA-4400(5μm, 4.6mm i.d.×250mm)
hexane / 2-propanol / methanol / trifluoroacetic acid (98 : 1 : 1 : 0.2)
UV 254 nm ｜ 1.0 mL / min ｜ 5μL (20 mg / mL)
SUMICHIRAL OA-4400(5μm, 4.6mm i.d.×250mm)
hexane / 1,2-dichloroethane / ethanol / acetic acid(500 : 150 : 10 : 1)
UV 254 nm ｜ 1.0 mL / min
SUMICHIRAL OA-4500(5μm, 4.0mm i.d.×250mm)
hexane / tetrahydrofuran / methanol / trifluoroacetic acid (60 : 35 : 5 : 0.2)
UV 254 nm ｜ 1.0 mL / min ｜ 1μL (1 mg / mL)
SUMICHIRAL OA-4500(5μm, 4.0mm i.d.×250mm)
hexane / tetrahydrofuran / methanol / trifluoroacetic acid (60 : 35 : 5 : 0.2)
UV 254 nm ｜ 1.0 mL / min ｜ 1μL (1 mg / mL)
- SUMICHIRAL Database
- Guidelines for Selection of SUMICHIRAL Columns
SUMICHIRAL OA-4600、OA-4700
Features
- Used for normal phase systems
- Applicable for a wide variety of compounds, such as aromatic amines and amides
- Able to inverse the elution order
- Supports SFC (supercritical fluid chromatography)
Active site
Product specification
| Product name | SUMICHIRAL OA-4600 | SUMICHIRAL OA-4700 |
|---|---|---|
| Chiral selectors | (S)-tert-Leucine， (S)-1-(α-Naphtyl) ethylamine |
(S)-tert-Leucine， (R)-1-(α-Naphtyl) etylamine |
| Support | High purity silica gel | |
| Partilcle size | 5μm | |
| Supporting mode | Chemically bonded | |
| Recommended mobile phase | Hexane/ethanol/trifluoroacetic acid | |
| Target compounds | Amines, amides, aminoalcohols, alcohols, esters, phosphamides | |
| Columns for elution order inversion | SUMICHIRAL OA-4600R | SUMICHIRAL OA-4700R |
Product list
| Product name | Internal diameter (mm) | Length (mm) | Product code |
|---|---|---|---|
| SUMICHIRAL OA-4600 | 4 | 10 | C-4601-4001W |
| 150 | C-4601-4015W | ||
| 250 | C-4601-4025W | ||
| 4.6 | 50 | C-4601-4605W | |
| 150 | C-4601-4615W | ||
| 250 | C-4601-4625W | ||
| 8 | 250 | C-4601-8025W | |
| 10 | 250 | C-460110025W | |
| 20 | 250 | C-460120025W | |
| SUMICHIRAL OA-4700 | 4 | 10 | C-4701-4001W |
| 150 | C-4701-4015W | ||
| 250 | C-4701-4025W | ||
| 4.6 | 50 | C-4701-4605W | |
| 150 | C-4701-4615W | ||
| 250 | C-4701-4625W | ||
| 8 | 250 | C-4701-8025W | |
| 10 | 250 | C-470110025W | |
| 20 | 250 | C-470120025W |
| Product name | Internal diameter (mm) | Length (mm) | Product code |
|---|---|---|---|
| SUMICHIRAL OA-4600R | 4 | 10 | C-4611-4001W |
| 150 | C-4611-4015W | ||
| 250 | C-4611-4025W | ||
| 4.6 | 50 | C-4611-4605W | |
| 150 | C-4611-4615W | ||
| 250 | C-4611-4625W | ||
| 8 | 250 | C-4611-8025W | |
| 10 | 250 | C-461110025W | |
| 20 | 250 | C-461120025W | |
| SUMICHIRAL OA-4700R | 4 | 10 | C-4711-4001W |
| 150 | C-4711-4015W | ||
| 250 | C-4711-4025W | ||
| 4.6 | 50 | C-4711-4605W | |
| 150 | C-4711-4615W | ||
| 250 | C-4711-4625W | ||
| 8 | 250 | C-4711-8025W | |
| 10 | 250 | C-471110025W | |
| 20 | 250 | C-471120025W |
- ※Note: Those shown in red are standard size for analysis.
Internal diameter of 4 mm and length of 10 mm is a guard column.
SUMIPAX Filter can be used in place of a guard column.
- Click here for SUMIPAX Filters
Applications
SUMICHIRAL OA-4600(5μm, 4.6mm i.d.×250mm)
hexane / ethanol (98 : 2)
UV 254 nm ｜ 1.0 mL / min
SUMICHIRAL OA-4600(5μm, 4.0mm i.d.×250mm)
hexane / 1,2-dichloroethane / methanol / trifluoroacetic acid (245 : 140 : 15 : 1)
UV 254 nm ｜ 1.0 mL / min ｜ 1μL (10 mg / mL)
SUMICHIRAL OA-4700(5μm, 4.6mm i.d.×250mm)
hexane / 2-propanol / methanol / trifluoroacetic acid (85 : 10 : 5 : 0.2)
UV 220 nm ｜ 1.0 mL / min ｜ 0.5μL (5 mg / mL)
SUMICHIRAL OA-4700(5μm, 4.6mm i.d.×250mm)
hexane / 2-propanol / methanol / trifluoroacetic acid (85 : 10 : 5 : 0.2)
UV 254 nm ｜ 1.0 mL / min ｜ 10μL (1 mg / mL)
- SUMICHIRAL Database
- Guidelines for Selection of SUMICHIRAL Columns
SUMICHIRAL OA-4800、OA-4900
Features
- Used for normal phase systems
- Applicable for a wide variety of compounds, such as aromatic amines and amides
- Supports SFC (supercritical fluid chromatography)
Active site
Product specification
| Product name | SUMICHIRAL OA-4800 | SUMICHIRAL OA-4900 |
|---|---|---|
| Chiral selectors | (S)-Indoline-2-carboxylic acid， (S)-1-(α-Naphtyl) ethylamine |
(S)-Indoline-2-carboxylic acid， (R)-1-(α-Naphtyl) ethylamine |
| Support | High purity silica gel | |
| Particle size | 5μm | |
| Supporting mode | Chemically bonded | |
| Recommended mobile phase | Hexane/ethanol/trifluoroacetic acid | |
| Target compounds | Amines, amides, aminoalcohols, alcohols, esters, phosphamides | |
Product list
| Product name | Internal diameter (mm) | Length (mm) | Product code |
|---|---|---|---|
| SUMICHIRAL OA-4800 | 4 | 10 | C-4801-4001W |
| 150 | C-4801-4015W | ||
| 250 | C-4801-4025W | ||
| 4.6 | 50 | C-4801-4605W | |
| 150 | C-4801-4615W | ||
| 250 | C-4801-4625W | ||
| 8 | 250 | C-4801-8025W | |
| 10 | 250 | C-480110025W | |
| 20 | 250 | C-480120025W | |
| SUMICHIRAL OA-4900 | 4 | 10 | C-4901-4001W |
| 150 | C-4901-4015W | ||
| 250 | C-4901-4025W | ||
| 4.6 | 50 | C-4901-4605W | |
| 150 | C-4901-4615W | ||
| 250 | C-4901-4625W | ||
| 8 | 250 | C-4901-8025W | |
| 10 | 250 | C-490110025W | |
| 20 | 250 | C-490120025W |
- ※Note: Those shown in red are standard size for analysis.
Internal diameter of 4 mm and length of 10 mm is a guard column.
SUMIPAX Filter can be used in place of a guard column.
- Click here for SUMIPAX Filters
Applications
SUMICHIRAL OA-4800(5μm, 4.6mm i.d.×250mm)
hexane / 2-propanol / methanol / trifluoroacetic acid (70 : 20 : 10 : 0.2)
UV 254 nm ｜ 1.0 mL / min ｜ 0.5μL (2 mg / mL)
SUMICHIRAL OA-4800(5μm, 4.6mm i.d.×250mm)
hexane / 1,2-dichloroethane / methanol / trifluoroacetic acid (70 : 20 : 10 : 0.2)
UV 254 nm ｜ 1.0 mL / min ｜ 5μL (3 mg / mL)
SUMICHIRAL OA-4900(5μm, 4.6mm i.d.×250mm)
hexane / ethanol (100 : 1)
UV 254 nm ｜ 1.0 mL / min
SUMICHIRAL OA-4900(5μm, 4.6mm i.d.×250mm)
hexane / 1,2-dichloroethane methanol / trifluoroacdetic acid (240 : 140 : 20 : 1)
UV 280 nm ｜ 1.0 mL / min
- SUMICHIRAL Database
- Guidelines for Selection of SUMICHIRAL Columns
日本住友化學(xué)代理
日本住友化學(xué)官網(wǎng)
歡迎訪問(wèn)日本住友化學(xué)SUMICHIRAL官網(wǎng)或者咨詢我們獲取更多相關(guān)產(chǎn)品信息。
SUMICHIRAL?選擇選擇方法
特征
Usable for both normal phase systems and reversed-phase systems (polar ionic phase) (water is not usable)
Applicable for LC-MS ? Ammonium acetate/methanol solution
Able to reverse the elution order
可用于正常相系統(tǒng)和反相系統(tǒng)(極性離子相)(水不可用)
適用于LC-MS?醋酸銨/甲醇溶液
能夠逆轉(zhuǎn)洗脫順序
活動(dòng)位點(diǎn)
| Product name | SUMICHIRAL OA-3100 | SUMICHIRAL OA-3200 | SUMICHIRAL OA-3300 |
|---|---|---|---|
| Chiral selectors | (S)-Valine | (S)-tert-Leucine | (R)-Phenylglycine |
| Support | High purity silica gel | ||
| Particle size | 5μm | ||
| Supporting mode | Chemically bonded | ||
| Recommended mobile phase | 【Nomal phase】 Hexane/ethanol/trifluoroacetic acid | ||
| 【Reversed phase (polar ionic phase)】 Methanol containing ammonium acetate | |||
| Target compounds | 【Normal phase】 Alcohols | ||
| 【Reversed phase (polar ionic phase)】 Carboxylic acids (amino N derivatives) | |||
| Columns for elution order inversion | SUMICHIRAL OA-3100R | SUMICHIRAL OA-3200R | SUMICHIRAL OA-3300S |
產(chǎn)品規(guī)格
| 產(chǎn)品名稱 | 骨關(guān)節(jié)炎-3100 | 骨關(guān)節(jié)炎-3200 | 骨關(guān)節(jié)炎-3300 |
|---|---|---|---|
| 手性選擇器 | (S)-Valine | (S)-叔亮氨酸 | (R)-苯甘氨酸 |
| 支撐 | 高純度硅膠 | ||
| 顆粒尺寸 | 5μm | ||
| 支撐模式 | 化學(xué)鍵合 | ||
| 推薦流動(dòng)階段 | [正常相]正己烷/乙醇/三氟乙酸 | ||
| [反相(極性離子相)]含乙酸銨甲醇 | |||
| 目標(biāo)化合物 | [正常相]酒精 | ||
| [反相(極性離子相)]羧酸(氨基N衍生物) | |||
| 洗脫反相柱 | 亞型OA-3100 R | 離體OA-3200 R | 亞臨界OA-3300 S |
產(chǎn)品清單
| 產(chǎn)品名稱 | 內(nèi)徑(毫米) | 長(zhǎng)度(毫米) | 產(chǎn)品代碼 |
|---|---|---|---|
| 骨關(guān)節(jié)炎-3100 | 2 | 150 | C-3101-2015W |
| 250 | C-3101-2025 W | ||
| 4 | 10 | C-3101-4001W | |
| 150 | C-3101-4015W | ||
| 250 | C-3101-4025 W | ||
| 4.6 | 50 | C-3101-4605W | |
| 150 | C-3101-4615 W | ||
| 250 | C-3101-4625 W | ||
| 8 | 250 | C-3101-8025W | |
| 10 | 250 | C-310110025W | |
| 20 | 250 | C-310120025W | |
| 骨關(guān)節(jié)炎-3200 | 2 | 150 | C-3201-2015W |
| 250 | C-3201-2025 W | ||
| 4 | 10 | C-3201-4001W | |
| 150 | C-3201-4015W | ||
| 250 | C-3201-4025 W | ||
| 4.6 | 50 | C-3201-4605W | |
| 150 | C-3201-4615 W | ||
| 250 | C-3201-4625 W | ||
| 8 | 250 | C-3201-8025W | |
| 10 | 250 | C-320110025W | |
| 20 | 250 | C-320120025W | |
| 骨關(guān)節(jié)炎-3300 | 2 | 150 | C-3301-2015W |
| 250 | C-3301-2025 W | ||
| 4 | 10 | C-3301-4001W | |
| 150 | C-3301-4015 W | ||
| 250 | C-3301-4025 W | ||
| 4.6 | 50 | C-3301-4605 W | |
| 150 | C-3301-4615 W | ||
| 250 | C-3301-4625 W | ||
| 8 | 250 | C-3301-8025W | |
| 10 | 250 | C-330110025W | |
| 20 | 250 | C-330120025W |
| 產(chǎn)品名稱 | 內(nèi)徑(毫米) | 長(zhǎng)度(毫米) | 產(chǎn)品代碼 |
|---|---|---|---|
| 亞型OA-3100 R | 2 | 150 | C-3111-2015W |
| 250 | C-3111-2025 W | ||
| 4 | 10 | C-3111-4001W | |
| 150 | C-3111-4015 W | ||
| 250 | C-3111-4025 W | ||
| 4.6 | 50 | C-3111-4605W | |
| 150 | C-3111-4615 W | ||
| 250 | C-3111-4625 W | ||
| 8 | 250 | C-3111-8025W | |
| 10 | 250 | C-311110025W | |
| 20 | 250 | C-311120025W | |
| 離體OA-3200 R | 2 | 150 | C-3211-2015 W |
| 250 | C-3211-2025 W | ||
| 4 | 10 | C-3211-4001W | |
| 150 | C-3211-4015 W | ||
| 250 | C-3211-4025 W | ||
| 4.6 | 50 | C-3211-4605 W | |
| 150 | C-3211-4615 W | ||
| 250 | C-3211-4625 W | ||
| 8 | 250 | C-3211-8025 W | |
| 10 | 250 | C-321110025W | |
| 20 | 250 | C-321120025W | |
| 亞臨界OA-3300 S | 2 | 150 | C-3311-2015 W |
| 250 | C-3311-2025 W | ||
| 4 | 10 | C-3311-4001W | |
| 150 | C-3311-4015 W | ||
| 250 | C-3311-4025 W | ||
| 4.6 | 50 | C-3311-4605 W | |
| 150 | C-3311-4615 W | ||
| 250 | C-3311-4625 W | ||
| 8 | 250 | C-3311-8025 W | |
| 10 | 250 | C-331110025W | |
| 20 | 250 | C-331120025W |
- ※注：用紅色表示的是分析的標(biāo)準(zhǔn)尺寸。
內(nèi)徑為4mm，長(zhǎng)度為10 mm為防護(hù)柱。
SUMIPAX過(guò)濾器可以用來(lái)代替保護(hù)列。
- 單擊此處獲取SUMIPAX過(guò)濾器
應(yīng)用
亞臨界OA-3100(5μm，4.0mm I.D.×250 mm)
0.03mol/L醋酸銨在甲醇中的含量
UV 254 nm/1.0 mL/min
-3100(5μm，4.6mm I.D.×250毫米)
0.01 mol/L醋酸銨在甲醇中的含量
UV 254 nm=1.0 mL/min 10μL(7 mg/mL)
亞顯微OA-3200(5μm，4.6mm I.D.×250 mm)
正己烷/2-丙醇/甲醇(70：20：10)
UV 254 nm/1.0 mL/min
亞顯微OA-3200(5μm，4.6mm I.D.×250 mm)
甲醇中0.005 mol/L醋酸銨
UV 254 nm/0.8mL/min
-3300(5μm，4.6mm I.D.×250毫米)
0.01 mol/L醋酸銨在甲醇中的含量
紫外254 nm-1.0 mL/min-0.4μL(10 mg/mL)
-3300(5μm，4.6mm I.D.×250毫米)
0.01 mol/L醋酸銨在甲醇中的含量
UV 254 nm=1.0mL/min 2μL(4mg/mL)
日本住友化學(xué)代理
日本住友化學(xué)官網(wǎng)
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SUMICHIRAL OA columns are high-performance chiral columns for
enantiomer separation by HPLC. On SUMICHIRAL OA columns direct
separation of various enantiomers can be realized effectively.
Enantiomeric separation is achieved from the various diastereomeric
interactions such as hydrogen bonding, charge transfer and host-guest
interactions, etc. SUMICHIRAL OA columns are very useful for the
accurate determination of the optical purity and for the preparation of
pure enantiomers of biologically active compounds such as
pharmaceuticals, pesticides, and perfumes.
■ Improved Pirkle Type
■ Ligand exchange Type
■ Host-guest Type
Improved Pirkle Type 1 Improved Pirkle Type 1
■Amide Type : Asymmetric carbon atoms are bonded directly with CONH group
OA-2000 series have a 3,5-dinitrobenzoyl group as theπ-acid and may interact with the solute
molecule by charge transfer, hydrogen bonding, etc. The enantiomers of aromatic compounds, esters,
carboxylic acids and alcohols may be directly separated on OA-2000 series. OA-2000 is especially
effective for pyrethroidal esters, OA-2500 for carboxylic acids such as profen-drugs.
■Urea Type : Asymmetric carbon atoms are bonded directly with NHCONH group
OA-3000 series have 3,5-dinitrophenylurea group as theπ-acid and, in the reverse phase mode,
promote chiral discrimination by charge transfer, hydrogen bonding, etc. In general OA-3000 series are
effective for carboxylic acids, and especially for acetyl- and urethane-amino acids, dansylamino acids.
OA-3300 offers good direct separation for profen-drugs, acetyl-amino acids, BOC-amino acids and
benzyl-amino acids.
Main columns : SUMICHIRAL OA-2500, SUMICHIRAL OA-3300
Special Merits of SUMICHIRAL OA
The large number of theoretical plates of the columns offer high
resolution.
The packing materials have chemical stability and the columns have
long life.
The enantiomeric stationary phases give the inverse elution orders
and so accurate determination of the optical purity and efficient
preparation of the enantiomer are attained.
Improved Pirkle Type 2 Improved Pirkle Type 2
Two chiral centers at amine and amino acid are bonded with NHCONH group
OA-4000 series have a naphthyl group as theπ-base, and two chiral centers at amine and amino
acid group. By charge transfer, hydrogen bonding, etc., chiral discrimination is acheived, and a wide
variety of compounds such as pharmaceuticals of amine and amino alcohols, alcohols, esters and
amides can be directly resolved in the normal phase mode. Amide and urethane derivatives of amines,
alcohols, etc. can be resolved effectively
Ligand exchange Type Ligand exchange Type
■The chiral components are coated hydrophobically on ODS
OA-5000 and 6000 series offer chiral discrimination by ligand exchange interaction in the
reversed phase mode. The chiral ligands such as penicillamine (OA-5000) or tartaric acid
derivatives (OA-6000 series) are coated on ODS silica, though the volume of organic solvents
added to the mobile phase is limited. Mobile phases including Cu++ ions are used in these
columns. They are effective for direct enantiomer separation of not only amino acids, hydroxy acids
but also copper-chelate forming compounds such as amino alcohols, diamines, dicarboxylic acids,
aminolactames and dipeptides. Especially OA-5000 can be applied for extremely wide range, while
OA-6100 is effective for β-amino acids,β-hydroxy acids and hydrophilic amino acids.
Main columns : SUMICHIRAL OA-5000, SUMICHIRAL OA-6100
Host-Guest Type
■Cyclodextrin bonded chiral stationary phase with novel spacer
OA-7000 is a novel chiral stationary phase with β-cyclodextrin bonded to the silica gel via new type of
spacer. A large number of racemates, including ketones, amines, and amino acid derivatives can be
separated under reversed phase conditions.
(1) Sharp peaks and high theoretical plate numbers are obtained.
Improved peak shape is due to the effect of hydrophilic spacer moiety which prevents secondary
interactions between the silica gel and the sample molecules.
(2) Popular reversed phase conditions can be used.
■Novel Chiral Stationary phase bonded with crown ether
OA-8000 is a novel chiral stationary phase bonded with chiral crown ether to aminopropyl silica gel. This
is very effective for enantiomer separations of amines, aminoalcohols and amino acids, especially for
hydrophobic amines.
(1) Stationary phase is covalent bond type and very stable.
(2) Both reversed and normal phases can be used.
(3) Sharp peaks and high theoretical plate numbers are obtained
| Standard type | Inverted type | Mode** | ||
| SUMICHIRAL | Chiral component | SUMICHIRAL | ||
| OA-2000 | (R)-phenylglycine | OA-2000S | NP | |
| ☆?OA-2500 | (R)-1-naphthylglycine | OA-2500S | RP | |
| OA-3100 | (S)-valine | OA-3100R | NP,RP | |
| OA-3200 | (S)-tert-leucine | OA-3200R | NP,RP | |
| ☆?OA-3300 | (R)-phenylglycine | OA-3300S | NP,RP | |
| OA-4000 | (S)-valine (S)-1-(α-naphthyl)ethylamine | OA-4000R | NP | |
| OA-4100 | (S)-valine (R)-1-(α-naphthyl)ethylamine | OA-4100R | NP | |
| OA-4400 | (S)-proline (S)-1-(α-naphthyl)ethylamine | OA-4400R | NP | |
| OA-4500 | (S)-proline (R)-1-(α-naphthyl)ethylamine | OA-4500R | NP | |
| OA-4600 | (S)-tert-leucine (S)-1-(α-naphthyl)ethylamine | OA-4600R | NP | |
| ☆?OA-4700 | (S)-tert-leucine (R)-1-(α-naphthyl)ethylamine | OA-4700R | NP | |
| OA-4800 | (S)-indoline-2-carboxylic acid | ＊ | NP | |
| (S)-1-(α-naphthyl)ethylamine | ||||
| ☆?OA-4900 | (S)-indoline-2-carboxylic acid | ＊ | NP | |
| (R)-1-(α-naphthyl)ethylamine | ||||
| ☆?OA-5000 | (D)-penicillamine | OA-5000L | RP | |
| OA-6000 | (L)-tartaric acid ?(S)-1-(α-naphthyl)ethylamine | OA-6000R | RP | |
| OA-6100 | (L)-tartaric acid, (S)-valine | OA-6100R | RP | |
| (R)-1-(α-naphthyl)ethylamine | ||||
| ☆?OA-7000 | β-cyclodextrin with novel spacer | ＊ | RP | |
| ☆?OA-8000 | chiral pseudo 18-crown-6 ether | ＊ | NP,RP |
Notation on the SUMICHIRAL database
SUMICHIAL標(biāo)簽的表示法
