日本 JaICA 老化Anti Malondialdehyde(MDA) monoclonal antibody
中文名稱：抗丙二醛單克隆抗體
英文名稱：Anti Malondialdehyde(MDA) monoclonal antibody
貨號(hào)：MMD-030n
規(guī)格：30ug
Anti MDA monoclonal antibody? 脂質(zhì)過氧化生物標(biāo)志物
適用于免疫組化（僅供研究使用）
About malondialdehyde (MDA)
Malondialdehyde (MDA) is one of the major aldehyde derive from lipid peroxidation. MDA is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with MDA and lysine residue leads to the formation of numerous numbers of adducts, such as dihydropyridine-lysine (DHP-lysine) type derivative. This monoclonal antibody is specific for the MDA-modified protein, especially DHP-lysine type derivative.
關(guān)于丙二醛（MDA）
丙二醛（MDA）是衍生自脂質(zhì)過氧化的主要醛之一。 MDA是高度反應(yīng)性的醛，并與蛋白質(zhì)中的賴氨酸殘基反應(yīng)。 與MDA和賴氨酸殘基的反應(yīng)導(dǎo)致眾多數(shù)量的加合物的形成，例如二氫吡啶-賴氨酸（DHP-賴氨酸）型衍生物。 該單克隆抗體對(duì)MDA修飾的蛋白質(zhì)，特別是DHP-賴氨酸型衍生物是特異性的。
Specifications
| Clone #: | 1F83 |
| Antigen: | MDA-modified keyhole-lympet hemocyanine. |
| Form: | Frozen (100 碌g/mL antibody in 10mM PBS containing 0.1% NaN3 and 0.5% BSA). Purified by Protein-A. |
| Application: | Immunohistochemistry. Recommended antibody concentration is 0.5-1.0 碌g/mL on paraformaldehyde fixed tissue. |
| Specificity: | MSpecific for MDA-modified protein (especially DHP-lysine). |
| Subclass: | Mouse IgG2a(lambda) |
| Storage: | Less than -20擄C |
Specificity of anti MDA antibody.
Immunohistochemical detection of MDA-modified protein in atherosclerotic aorta.
Dr. N Shibata, Tokyo Women’s Medical University.
技術(shù)參數(shù)
克隆號(hào)＃：1F83；
抗原：MDA修飾的鑰孔血藍(lán)蛋白（KLH）；
性狀：凍結(jié)（100μg/mL抗體在含有0.1％NaN3和0.5％ BSA的10mM PBS中），經(jīng)過蛋白A純化；
應(yīng)用：免疫組織化學(xué)。對(duì)多聚甲醛固定的組織推薦抗體濃度為0.5-1.0μg/mL；
特異性：特異性針對(duì)MDA修飾的蛋白（特別是DHP-賴氨酸）。
亞基：小鼠IgG2a（lambda）
儲(chǔ)存：小于-20℃
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References 參考文獻(xiàn)
| 1) | Immunochemical detection of a lipofuscin-like fluorophore derivered from malondialdehyde and lysine. S Yamada, S Kumazawa, T Ishii, T Nakayama, K Itakura, N Shibata, M Kobayashi, K Sakai, T Osawa and K Uchida. J.Lipid Res. 42, p1187-1196 (2001) |
| 2) | Investigation on the Origin of Sperm DNA Fragmentation: Role of Apoptosis, Immaturity and Oxidative Stress. Muratori M, Tamburrino L, Marchiani S, Cambi M, Olivito B, Azzari C, Forti G, Baldi E Mol Med. 21,p109-122(2015). doi: 10.2119/molmed.2014.00158. |
日本 JaICA 老化Anti Malondialdehyde(MDA) monoclonal antibody技術(shù)資料：http://www.jaica.com/e/technical_forum_nof.html#MDA
日本 JaICA 老化Anti Malondialdehyde(MDA) monoclonal antibody 說明書：
http://www.jaica.com/e/pdf/mda_ab_manual.pdf