日本 JaICA 老化Anti Acrolein (ACR) monoclonal antibody
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日本老化制御研究所?Jaica代理
抗丙烯醛單克隆抗體 Anti Acrolein(ACR) monoclonal antibody
Suitable for immunohistocheistry. For research use only.
Acrolein (ACR) is a representative carcinogenic aldehyde found ubiquitously in the environment and formed endogenously through oxidation reactions, such as lipid peroxidation and myeloperoxidasecatalyzed amino acid oxidation. ACR is highly reactive aldehyde and reacts with lysine residue in protein. The reaction with ACR and lysine residue leads to the formation of numerous numbers of adducts, such as formyl-dehydropiperidino-lysine (FDP-lysine) type derivative. This antibody is specific for the ACR-modified protein, especially FDP-lysine type derivative.
Specification
| Clone #: | 5F6 |
| Antigen: | ACR-modified keyhole-lympet hemocyanine |
| Form: | Frozen (100 碌g/mL antibody in 10mM PBS containing 0.1% NaN3?and 0.5% BSA). Purified by Protein-A. |
| Application: | Immunohistochemistry. Recommended antibody concentration is 0.5-1.0 碌g/mL on paraformaldehyde fixed tissue. |
| Specificity: | Specific for ACR-modified protein (especially FDP-lysine type derivative) |
| Subclass: | Mouse IgG1,kappa |
| Storage: | Less than-20°C |
抗丙烯醛單克隆抗體適用于免疫組織化學(xué)。
丙烯醛（ACR）是在環(huán)境中普遍存在并且通過氧化反應(yīng)（例如脂質(zhì)過氧化和髓過氧化物酶催化的氨基酸氧化）內(nèi)源性形成的代表性致癌醛。 ACR是高度反應(yīng)性的醛，并與蛋白質(zhì)中的賴氨酸殘基反應(yīng)。與ACR和賴氨酸殘基的反應(yīng)導(dǎo)致大量的加合物的形成，例如formyl-dehydropiperidino-lysine（FDP-賴氨酸）類型衍生物。
該抗體對ACR修飾的蛋白，特別是FDP-賴氨酸類型衍生物具有特異性。
技術(shù)參數(shù)
克隆＃：5F6；
抗原：ACR修飾的鑰孔血藍蛋白；
形式：凍結(jié)（100μg/ mL抗體在含有0.1％NaN3和0.5％BSA的10mM PBS中）。通過蛋白A純化；
應(yīng)用：免疫組織化學(xué)；
推薦抗體濃度：0.5-1.0μg/ mL對于多聚甲醛固定的組織；
特異性：特定針對ACR修飾的蛋白（特別是FDP-賴氨酸類型衍生物）；
亞型：小鼠IgG1，kappa；
儲存：小于-20°C
References
1)Protein-bound acrolein: Potential markers for oxidativestress. K.Uchida, M.Kanematsu, K.Sakai, T.Matsuda, N.Hattori,Y.Mizuno, D.Suzuki,T.Miyata, N.Noguchi, E.Niki,T.Osawa
Proc.Natl.Acad.Sci.USA,95,4882-4887(1998)
2)Protein-bound acrolein: A novel markers of oxidativestress in Alzheimer’s Disease. Noel Y. Calingasan, Koji Uchida, and Gary E.Gibson
Journal of Neurochemistry.72(2),751-756(1999)
| Product name | Code | Content |
| Anti Acrolein monoclonal antibody | MAR-020n | 20 ug of IgG |
| MAR-100n | 100 ug of IgG |
日本 JaICA 老化Anti Acrolein monoclonal antibody
抗丙烯醛（ACR）單克隆抗體 使用使用說明書