日本住友化學(xué) SUMICHIRAL色譜柱 OA-SHELL P1

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日本住友化學(xué) SUMICHIRAL色譜柱 OA-SHELL P1

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Core-shell type chiral stationary phase
SUMICHIRALTM?OA-SHELL P1
Advantages

SUMICHIRALTM?OA-SHELL P1 is our first chiral stationary phase using optical active polymer. It is effective for chiral separation of compounds without amino group or carboxyl group，which are generally difficult to separate with conventional chiral stationary phases. Especially, it shows excellent resolution for aromatic chiral alcohol compounds. Core‐shell silica is used as a support and coated with poly (diphenylacetylene) derivative (optically active spiral polymer).

【Advantages of SUMICHIRALTM??OA-SHELL P1】

Chiral stationary phase using core-shell silica support

★?Analysis time could be shortened with conventional HPLC ★

  • Effective for chiral separation of compounds without amino group or carboxyl group ★
  • Easy method development with simple mobile phase compositions ★
  • Excellent durability, lot-to-lot repeatability ★

Unlike full porous particles, the core-shell particle has a non-porous core in the center and a thin porous layer outside of the core.

【Method development 】

SUMICHIRALTM?OA-SHELL P1 makes it easy to set the conditions of mobile phase. The scheme of the general method development is shown in the right figure. For neutral compounds such as aromatic alcohols, it is not usually necessary to add special modifiers. For acidic compounds, add trifluoroacetic acid.

  • Do not use the following solvents as they will cause the column to deteriorate : tetrahydrofuran, 1,2-dichloroethane, chloroform, ethyl acetate, acetone, etc.

Standard mobile phase n-hexane/2-propanol（95/5）

Change the concentration of 2 -propanol and adjust the retention time

（concentration of 2-propanol 0～20％）

Change 2-propanol to ethanol

（concentration of ethanol 0～10％）

For acidic compounds etc., add trifluoroacetic acid

【Durability test】 （concentration of trifluoroacetic acid 0.02～0.1％）

SUMICHIRALTM?OA-SHELL P1 has excellent durability despite the use of optically active polymers as chiral selectors. The mobile phase was continuously fed to the column, and the stability was evaluated under the following conditions. As a result, almost no change was observed in separation factor, resolution, retention time, and column pressure.

Conditions

mobile phase：n-hexane / ethanol（95/5）

flow rate：0.2 ｍL/min detection：UV254 nm

column temperature：25℃

sample：trans-2-phenyl-1-cyclohexanol 10

Ordering information

 

【Specification of SUMICHIRALTM?OA-SHELL P1】

 

chiral selector core-shell silica support
particle size pore size specific surface area
poly (diphenylacetylene) 2.6 μm 250～280? 40～60 m2/g
derivative

 

【List of SUMICHIRALTM?OA-SHELL P1】
particle size internal diameter column length P/N
（μｍ） （mm） （mm）
50 C-SP01-3005W
2.6 3.0 100 C-SP01-3010W
150 C-SP01-3015W

【List of guard filter】

For column protection, we recommend porous glass guard filter “SUMIPAXTM?Filter PG-ODS for semi-micro “.

product name contents P/N
SUMIPAXTM?Filter Starter kit PG-ODS SUS holder 1 pcs GMODS001
for semi-micro filter 1 pcs
SUMIPAXTM?Filter PG-ODS replacement filter 8 pcs GMODS002
Replacement filter for semi-micro
SUMIPAXTM??Holder for semi-micro SUS holder 1 pcs GMACC001
Connection kit for semi-micro ferrule screw 2 pcs GMACC002
SUS tube 1 pcs

【Column selection】

There are many kinds of SUMICHIRALTM?series columns, so it is important to select the optimum column depending on the target compounds. Since you can use the database of chiral applications on our website and search application data from compound names and functional group information, please refer to the column selection.

  • SUMICHIRALTMand SUMIPAXTM?are registered trademarks in Japan.
  • For prices and column sizes other than the above, please contact our distributor.