Research?Diets 脂肪肝造模飼料Fatty Liver

Research?Diets 脂肪肝造模飼料Fatty Liver

Research Diets代理
Research Diets 私立代理
Research Diets 部分現(xiàn)貨

Research?Diets?公司是一家專(zhuān)業(yè)的生產(chǎn)科研實(shí)驗(yàn)室動(dòng)物飼料的大型公司,產(chǎn)品包括高脂、高糖、脂肪肝、酒精肝、動(dòng)脈硬化、缺鐵性貧血飼料、骨質(zhì)疏松飼料等飼料的世界著名的供應(yīng)商。

適用動(dòng)物

生產(chǎn)的飼料適用的動(dòng)物有:大鼠、小鼠、豚鼠、倉(cāng)鼠、兔子、豬及靈長(zhǎng)類(lèi)動(dòng)物等。

NAFLD (Non-alcoholic Fatty Liver Disease)

NAFLD encompasses a spectrum of disease states, from steatosis (fatty liver) to non-alcoholic steatohepatitis (also called NASH; steatosis with inflammatory changes) followed by progression to fibrosis, cirrhosis and hepatocellular carcinoma. Excess liver fat is believed to be a manifestation of the metabolic syndrome and not surprisingly NASH is associated with obesity, insulin resistance, dyslipidemia and type II diabetes in humans. Most obese adults have hepatic steatosis and at least one-third of these individuals will eventually develop worsening NAFLD. Therefore, the prevalence of NAFLD will likely rise with obesity rates.

As with many human diseases, fatty liver in rodents is also diet-inducible. Different dietary approaches produce different severities of disease along the NAFLD spectrum and likely work by unique mechanisms. Therefore it is important for the researcher to choose the diet that best suits the needs of their study. Contact one of our scientists for advice. To read more, see our Product Literature.

Product Literature

Types of Diets methionine and choline deficient (MCD) diet, choline-deficient diet (CD), high-fat diet (HFD)
Commonly Used Strains C57BL/6, LDLR (-/-) mice, Sprague Dawley rats
Matched Control Diet Purified Ingredient match*

非酒精性脂肪肝

NAFLD包括一系列疾病,從脂肪變性(脂肪肝)到非酒精性脂肪性肝炎(也稱(chēng)為NASH;脂肪變性伴有炎癥變化),然后發(fā)展為纖維化、肝硬化和肝細(xì)胞癌。過(guò)量的肝臟脂肪被認(rèn)為是代謝綜合征的一種表現(xiàn),毫不奇怪,NASH與肥胖、胰島素抵抗、血脂異常和II型糖尿病有關(guān)。大多數(shù)肥胖成年人有肝臟脂肪變性,其中至少三分之一的人最終會(huì)發(fā)展為惡化的NAFLD。因此,NAFLD的患病率可能會(huì)隨著肥胖率的增加而上升。

和許多人類(lèi)疾病一樣,嚙齒類(lèi)動(dòng)物的脂肪肝也是由食物引起的.不同的飲食方法在NAFLD譜上會(huì)產(chǎn)生不同程度的疾病,并可能通過(guò)獨(dú)特的機(jī)制發(fā)揮作用。因此,對(duì)于研究者來(lái)說(shuō),選擇最適合他們研究需要的飲食是很重要的。聯(lián)系我們的一位科學(xué)家尋求建議。要閱讀更多,請(qǐng)參閱我們的產(chǎn)品文獻(xiàn)。

產(chǎn)品文學(xué)

飲食類(lèi)型 蛋氨酸和膽堿缺乏(Mcd)飲食,膽堿缺乏飲食(Cd),高脂飲食(Ffd)。
常用菌株 C57BL/6,LDLR(-/-)小鼠,Sprague Dawley大鼠
匹配控制飲食 純化成分匹配*

*對(duì)于那些需要匹配的對(duì)照飲食的人,一定要使用純成分匹配的飲食,而不是以谷物為基礎(chǔ)的飲食。