日本關(guān)東化學(xué) Kanto Nickel Catalyst for Direct Cross Coupling（Ni-dcype）

Cross coupling reaction is one of?the?useful reactions in the?organic syntheses and is

widely used?for the syntheses of?pharmaceuticals, agricultural materials,?bioactive com-

pounds, and organic?electrochemical materials.

Our company?launched a new Ni catalyst (Ni-dcype) developed by?Prof.?Kenichiro?Itami,

Prof. Junichiro?Yamaguchi?of Institute of?Transformative Bio-Molecules (WPI-ItbM),

Nagoya University.?Cross coupling products are obtainable in high yields using?this cata-

lyst?by?the?reaction?of?heteroaromatic compounds?with phenol?derivatives, aromatic

compounds bearing ester functions, enol compounds, or α,β-unsaturated?esters.

1,2‐Bis(dicyclohexylphosphino)ethane]dicarbonylnickel? ? CAS No：141974-66-5

Byname Ｎｉ‐ｄｃｙｐｅ
Formula (C6H11)2PCH2CH2P(C6H11)2Ni(CO)2
Formula weight ：537.32
CAS No：141974-66-5

Advantages of this reaction

■New?type?of?cross?coupling?reaction,?which?is?not?conducted?with?the

previous?catalysts

■Green?reaction?without?using?of?oraganometallic?substrates?and?organic

halogen compounds

■Ubiquitous Ni catalyst (non-use Pd)

Related?products

1,2-Bis(dicyclohexylphosphino)ethane? CAS：23743-26-2? FW：422.60

04874-45? ? 04874-65

Bis(1,5-cyclooctadiene)nickel? CAS：1295-35-8? FW：275.06

04875-65? ? 04875-55

Dicarbonylbis(triphenylphosphine)nick? CAS：13007-90-4? FW：639.28

11235-55? ? 5 g

References

1)Amaike, K.;?Muto, K.; Yamaguchi, J.;?Itami, K.?J. Am. Chem. Soc.?2012,?134, 13573.

2)Muto, K.; Yamaguchi, J.;?Itami, K. J.?Am. Chem. Soc. 2012,?134, 169.

3)Meng, L.; Kamada, Y.; Muto, K.; Yamaguchi, J.; Itami, K.?Angew. Chem. Int. Ed. 2013,?52, 10048.