屬性

質(zhì)量水平

200

形式

viscous liquid

分子量

average Mn~10,000 by GPC
average Mw~25,000 by LS

雜質(zhì)

≤1% water

折射率

n20/D 1.5290

粘度

13,000-18,000(50°C)

bp

250°C (lit.)

密度

1.030g/mLat 25°C

SMILES string

C1CN1

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI key

NOWKCMXCCJGMRR-UHFFFAOYSA-N

說明

一般描述

Polyethylenimine (PEI) is a hydrophilic cationic polymer widely used as a nonviral nucleotide delivery reagent. Branched PEI can be synthesized by cationic ring-opening polymerization of aziridine. PEI-based particles can also be used as adjuvants for vaccines. Owing to its excellent physicochemical properties, it is applied in many fields like the separation and purification of proteins, carbon dioxide absorption, drug carriers, effluent treatment, and biological labels.

應(yīng)用

用作帶電表面上的聚電解質(zhì)多層膜，為該表面提供生物相容涂層。[1]
洗滌劑、粘合劑、水處理、油墨、染料、化妝品、造紙業(yè)、助粘劑、層壓底漆、固色劑、絮凝劑、陽離子分散劑、穩(wěn)定增強(qiáng)劑、表面活性劑、螯合劑以及醛類和氧化物清除劑。

Polyethyleneimine can be used as a non-viral synthetic polymer vector forin vivodelivery of therapeutic nucleic acids. The interaction between negatively charged nucleic acids and positively charged polymer backbone results in the formation of nano-sized complexes. This neutralized complex protects the enclosed nucleic acid from enzymes and maintains its stability till the cellular uptake takes place. For example, human serum albumin conjugated PEI shows good pDNA transfection and low toxicity.

PEI can be used to functionalize single-walled nanotubes (SWNTs) to improve their solubility and biocompatibility while maintaining the structural integrity of the original SWNT. Covalently functionalized SWNTs find application in CO2absorption and gene delivery.

Branched PEI can also be used to modify the surface properties of adsorbents. PEI-modified hydrous zirconium oxide/PAN nanofibers are used for the defluorination of groundwater as they show high fluoride adsorption capacity and a wide working pH range.

包裝

100, 250 mL in poly bottle

1 L in poly bottle

特點和優(yōu)勢

Primary and secondary amine groups of PEI can efficiently bind to drugs, nucleic acids, and other functional moieties.

Branched PEI has better complexation andbuffering capacity.

外形

支化聚合物