Research Diets 糖尿病/胰島素抵抗模型飼料
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Research Diets部分現(xiàn)貨
糖尿病/胰島素抵抗??Diabetes/ Insulin Resistance
精制碳水化合物來源,如高果糖玉米糖漿(HFCS)被用于許多加工食品,在美國的調(diào)查表明,這種甜味劑的攝入量自20世紀70年代以來急劇增加。正如我們在過去幾十年中所了解到的,攝入過量的精制碳水化合物與人和動物模型中體重增加、高甘油三酯血癥(Hyper-TG)和胰島素抵抗(IR)有關。為了更多地了解精制碳水化合物對健康的影響和減少代謝綜合征(MS)表型的療法,某些嚙齒動物模型是有用的。含有約60%~70%的果糖或蔗糖(果糖和葡萄糖的摩爾比例為50:50)的純化飼料能夠提高肝臟的TG和葡萄糖產(chǎn)量,最終導致IR和高TG相對于以葡萄糖為主要糖源的日糧(即葡萄糖、玉米淀粉)。要閱讀更多,請參閱我們的產(chǎn)品文獻。
Refined carbohydrate sources such as high fructose corn syrup (HFCS) are used in many processed foods and surveys in the U.S. have suggested that the intake of this sweetener has increased dramatically since the 1970s. As we have learned over the past few decades, an excess intake of refined carbohydrates is associated with increased weight gain, hypertriglyceridemia (hyper-TG), and insulin resistance (IR) in humans and animal models. In order to understand more about the impact of refined carbohydrates on health and therapies to reduce these metabolic syndrome (MS) phenotypes, certain rodent models have been useful. Purified diets containing around 60% – 70% (by energy) fructose or sucrose (which is a 50:50 molar mixture of fructose and glucose) are capable of elevating TG and glucose production in the liver, ultimately leading to IR and hyper-TG relative to diets containing mainly glucose carbohydrate sources (i.e. dextrose, corn starch). To read more, see our Product Literature.
Product Literature
Types of Diets | High fructose, High sucrose |
Commonly Used Strains | Sprague-Dawley, Wistar rats, Hamsters, C57BL/6, LDLr KO |
Matched Control Diets | Purified Ingredient match* |
*For those requiring a matched control diet, be sure to use a purified ingredient matched diet rather than a grain-based diet.
產(chǎn)品文學
飲食類型 | 高果糖,高蔗糖 |
常用菌株 | Sprague-Dawley,Wistar大鼠,倉鼠,C57BL/6,LDLR KO |
配對對照日糧 | 純化成分匹配* |
*對于那些需要匹配的對照飲食的人,一定要使用純成分匹配的飲食,而不是以谷物為基礎的飲食。