Lumiprobe Cy7.5-N-羥基琥珀酰亞胺酯

Lumiprobe Cy7.5-N-羥基琥珀酰亞胺酯

  • 英文名:Cyanine7.5 NHS ester
  • 分子式:C49H52ClN3O4
  • 分子量:782.41
  • 品牌:lumiprobe
  • 外觀:green powder
訂購貨號 產(chǎn)品名稱及規(guī)格
16020 Cyanine7.5 NHS ester, 1 mg
26020 Cyanine7.5 NHS ester, 5 mg
46020 Cyanine7.5 NHS ester, 25 mg
56020 Cyanine7.5 NHS ester, 50 mg
66020 Cyanine7.5 NHS ester, 100 mg

Cyanine7.5是一種近紅外熒光染料,具有很長的發(fā)射光譜,是此類熒光衍生而來的活性胺產(chǎn)品。近紅外照射很容易穿透組織因此常應(yīng)用于體內(nèi)成像領(lǐng)域。該產(chǎn)品可以用于標(biāo)記含有氨基的小分子物質(zhì),比如蛋白和多肽,通過近紅外光譜成像技術(shù)(NIR imaging)來示蹤他們在有機(jī)體內(nèi)的分布。中心聚亞甲基基團(tuán)的增強(qiáng)的穩(wěn)定性使得量子產(chǎn)率較其母結(jié)構(gòu)Cy7.5? NHS提高20%。

Cy? is a trademark of GE Healthcare.
General properties

Appearance: green powder
Molecular weight: 782.41
Molecular formula: C49H52ClN3O4
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H (95%) and 13C, TLC, functional testing
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download

Spectral properties

Excitation maximum, nm: 788
Extinction coefficient at excitation maximum, Lmol-1cm-1: 223000
Emission maximum, nm: 808

Product citations

  • Zhang, Z.; Cai, H.; Liu, Z.; Yao, P.?Effective Enhancement of Hypoglycemic Effect of Insulin by Liver-targeted Nanoparticles Containing Cholic Acid-modified Chitosan Derivative.?Molecular Pharmaceutics, in press. doi:10.1021/acs.molpharmaceut.6b00188
  • Dou, Y.; Guo, J.; Chen, Y.; Han, S.; Xu, X.; Shi, Q.; Jia, Y.; Liu, Y.; Deng, Y.; Wang, R.; Li, X.; Zhang, J.?Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice.?Journal of Controlled Release,?2016, 235, 48–62. doi:?10.1016/j.jconrel.2016.05.049
  • Markovic, S.; Belz, J.; Kumar, R.; Cormack, R.A.; Sridhar, S.; Niedre, M.?Near-infrared fluorescence imaging platform for quantifying?in vivo?nanoparticle diffusion from drug loaded implants.?International Journal of Nanomedicine,?2016, 11, 1213–1223. doi:?10.2147/IJN.S93324
  • Han, F.Y.; Thurecht, K.J.; Lam, A.-L.; Whittaker, A.K.; Smith, M.T.?Novel Polymeric Bioerodable Microparticles for Prolonged-Release Intrathecal Delivery of Analgesic Agents for Relief of Intractable Cancer-Related Pain.?Journal of Pharmaceutical Sciences,?2015, 104(7), 2334–2344. doi:?10.1002/jps.24497
  • Duong, H.T.T.; Dong, Z.; Su, L; Boyer, C.; George, J.; Davis, T.P.; Wang, J.?The Use of Nanoparticles to Deliver Nitric Oxide to Hepatic Stellate Cells for Treating Liver Fibrosis and Portal Hypertension.?Small,?2015, 11(19), 2291–2304.201402870
  • Chen, K.; Xu, X.; Guo, J.W.; Zhang, X.; Han, S.; Wang, R.; Li, X.; Zhang, J.?Enhanced Intracellular Delivery and Tissue Retention of Nanoparticles by Mussel-Inspired Surface Chemistry.?Biomacromolecules,?2015, 16(11), 3574–3583. doi:10.1021/acs.biomac.5b01056
  • Lin, Y.-A.; Cheetham, A.G.; Zhang, P.; Ou, Y.-C.; Li, Y.; Liu, G.; Hermida Merino, D.; Hamley, I.W.; Cui, H.?Multi-Walled Nanotubes Formed by Catanionic Mixtures of Drug Amphiphiles.?ACS Nano,?2014, 8(12), 12690-12700. doi:?10.1021/nn505688b
  • Graen, T.M.D.; Hoefling, M.; Grubmüller, H.?AMBER-DYES: Characterization of Charge Fluctuations and Force Field Parameterization of Fluorescent Dyes for Molecular Dynamics Simulations.?Journal of Chemical Theory and Computation,?2014, 10(12), 5505-5512. doi:?10.1021/ct500869p
  • Lu, H.D.; Soranno, D.E.; Rodell, C.B.; Kim, I.L.; Burdick, J.A.?Secondary Photocrosslinking of Injectable Shear-Thinning Dock-and-Lock Hydrogels.?Advanced Healthcare Materials,?2013, 2(7), 1028-1036. doi:?10.1002/adhm.201200343
  • Yang, H.; Mao, H.; Wan, Z.; Zhu, A.; Guo, M.; Li, Y.; Li, X.; Wan, J.; Yang, X.; Shuai, X. et al.?Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy.?Biomaterials,?2013, 34(36), 9124-9133. doi:?10.1016/j.biomaterials.2013.08.022