分類目錄歸檔：Harlan飼料

Harlan TD.07108 Zn Defic. Diet (0.5) 鋅缺乏飼料使用說明書

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Harlan TD.07108 Zn Defic. Diet (0.5) 鋅缺乏飼料使用說明書

Harlan Teklad動物飼料
Harlan代理–上海金畔生物科技有限公司
歡迎新老客戶訪問Harlan官網或者咨詢代理上海金畔生物獲取更多詳細資料。

TD.85419? is 0.5 – 1.5 ppm，Diet TD.07108 is a modification of TD.85419 with 0.5 ppm added zinc as zinc sulfate and purple food coloring. Total zinc is estimated to be 2 – 3.5 ppm (background + added zinc)

TD.85419是0.5 – 1.5 ppm，飲食TD.07108是TD.85419的改良形式，添加了0.5 ppm的鋅作為硫酸鋅和紫色食用色素。 總鋅估計為2-3.5 ppm（基礎鋅含量+添加的鋅）

Harlan Teklad Custom Diet
TD.07108 Zn Defic. Diet (0.5)

Formula g/Kg
Egg White Solids, spray-dried 200
Dextrose, monohydrate 634.2376
Corn Oil 100
Cellulose 29.986
Mineral Mix, Zn Deficient (81264) 25.6902
Chromium Potassium Sulfate, dodecahydrate 0.02
Zinc Sulfate, heptahydrate 0.0022
Vitamin Mix, Teklad (40060) 10
Biotin 0.004
Ethoxyquin, antioxidant 0.02
Purple Food Color 0.04

Footnote

A zinc deficient diet with 0.5 ppm added zinc as zinc sulfate and purple food coloring. Total zinc estimated to be 2 – 3.5 ppm (background + added zinc). Modified from TD.85419. For the series TD.07108-TD.07110.

Selected Nutrient Information1

% by weight % kcal from
Protein 16.1 16.6
Carbohydrate 58.3 60.1
Fat 10.0 23.2
Kcal/g 3.9
  • Values are calculated from ingredient analysis or manufacturer data

Key Features

  • Purified Diet
  • Adjusted Zinc
  • Color Coded
  • Zinc Sulfate

Key Planning Information

  • Products are made fresh to order
  • Store product at 4°C or lower
  • Use within 6 months (applicable to most diets)
  • Box labeled with product name, manufacturing date, and lot number
  • Replace diet at minimum once per week

More frequent replacement may be advised

  • Lead time:
  • 2 weeks non-irradiated
  • 4 weeks irradiated

Harlan Teklad 2018 global 18% protein rodent diets

發(fā)表于由

Harlan Teklad 2018? global 18% protein rodent diets

Harlan Teklad動物飼料
Harlan代理–上海金畔生物科技有限公司
歡迎新老客戶訪問Harlan官網或者咨詢上海金畔生物獲取更多詳細資料。

2018年全球18%蛋白質嚙齒類飼料

Home + Teklad diet, bedding and enrichment + Teklad laboratory animal diets + Standard natural ingredient diets + Rodent diets + 2018 Teklad global 18% protein rodent diets

Product Features

  • Designed to support gestation, lactation, and growth
  • Formulated to reduce soybean meal, thus minimizing the presence of isoflavones, the primary type of?phytoestrogen?found in lab animal diets
  • Typical isoflavone concentrations (daidzein + genistein aglycone equivalents) range from 150 to 250 mg/kg
  • Exclusion of alfalfa reduces chlorophyll, greatly improving?fluorescent optical imagingclarity
  • Absence of animal protein and fish meal minimizes the presence of nitrosamines (a potential carcinogen)
Products
Teklad rodent diets Non-autoclavable form Autoclavable Irradiated
Teklad global 18% protein 2018, 2018C 2018S,?2018SX 2918
Not all products are stocked locally; extended lead time and additional fees may apply.
Many diets are available in certified format designated by a “C” following the product code. When diets are certified a representative sample is tested for a panel of contaminants. If not stocked as certified, certification can be made available upon request. Minimum order size and additional charges may apply.

產品特點

  • 用于支持妊娠、哺乳和生長的
  • 減少豆粕的配方，從而盡量減少異黃酮的存在。異黃酮是大豆的主要類型。植物雌激素在實驗室動物飲食中發(fā)現(xiàn)的
  • 典型的異黃酮濃度(大豆苷元+染料木素苷元當量)為150至250毫克/千克。
  • 紫花苜蓿的排斥降低了葉綠素含量，大大提高了葉綠素含量。熒光光學成像清晰性
  • 缺乏動物蛋白質和魚粉可使亞硝胺(一種潛在的致癌物質)的存在減少到最低限度。
產品
特克勒德嚙齒類食物 不可蒸壓式 高壓釜 輻照
Teklead全局18%蛋白 2018，2008 c 2008 S,?2018SX 2918
并不是所有的產品都是在當?shù)貛齑娴?，可能需要延長交貨期和額外的費用。
許多飲食都是由符合產品代碼的“C”指定的認證格式提供的。當飲食被認證時，一個有代表性的樣本會被測試一組污染物。如果沒有經過認證的庫存，可以根據(jù)要求提供認證。可適用最低訂貨量和附加費用。

Harlan Teklad 誘導動物NAFLD and NASH飼料

發(fā)表于由

Harlan Teklad 誘導動物NAFLD and NASH飼料

Teklad diet, bedding and enrichment? ? Teklad laboratory animal diets? ?Custom research diets? ?NAFLD and NASH

誘導嚙齒動物NAFLD/NASH的飲食方法可分為兩大類：

  • 長期喂飼可誘發(fā)肥胖、代謝綜合癥及輕微納什或
  • 短時間喂飼可誘發(fā)嚴重納什的肝臟特征而不引起肥胖或胰島素抵抗的飲食。

下表突出了上述兩個類別的飲食選擇。有關NAFLD/NASH模型的更完整描述，請參見表后面的下拉菜單。

Dietary methods to induce NAFLD/NASH in rodents can be split into two common categories:

  • diets fed for longer periods of time to induce obesity, metabolic syndrome, and mild NASH or
  • diets fed for short periods of time to induce hepatic features of severe NASH without inducing obesity or insulin resistance

This page provides further information on dietary methods to induce NAFLD/NASH.?We’ve also prepared a?downloadable?NASH/NAFLD mini paper.

The tables below highlight diet options from both of the above categories. For more complete descriptions of NAFLD/NASH models see the drop down menus that follow the tables.

Diet options for inducing obesity, metabolic syndrome and mild NAFLD/NASH
Diet features Western/Fast Food ALIOS FPC diet
Product Code TD.88137 TD.06303 TD.160785?PWD?dough

TD.190142?pellet
Fat, % Kcal 42 45 52
Fat Sources,
% by weight		 21% milk fat 22%?hydrogenated vegetable oil
1% soybean oil		 19%?hydrogenated vegetable oil
6% milk fat
4% palmitic acid
Fatty acid profile,
% total fat		 66% saturated
30% monounsaturated
4% polyunsaturated		 23% saturated
31% monounsaturated (cis)
12% polyunsaturated (cis)
34% trans		 43% saturated
27% monounsaturated (cis)
7% polyunsaturated (cis)
23% trans
Sugars, % by weight 34.5% sucrose 22.4% sucrose 34.5% sucrose
Cholesterol, % by weight 0.2 0 1.25
Modifications TD.96121?1.25% cholesterol
TD.120528?Increased sucrose, 1.25% cholesterol		 TD.120330?0.2% cholesterol
TD.130885?0.2% cholesterol, 27% sucrose		 TD.140154?adds customer supplied palmitic acid

For high fat diet options to induce uncomplicated NAFLD see our?Diet Induced Obesity page.

Diet options for inducing more severe hepatic NAFLD/NASH without obesity or metabolic syndrome
Diet features High Fat, Cholesterol & Cholate Methionine/choline deficient (MCD)
Product Code TD.02028 TD.90262
Fat, % Kcal 42 22
Fat Sources,
% by weight		 21% milk fat 10% corn oil
Fatty acid profile,
% total fat		 66% saturated
30% monounsaturated
4% polyunsaturated		 14% saturated
28% monounsaturated
58% polyunsaturated
Sugars, % by weight 33.3% sucrose 46% sucrose
Cholesterol, % by weight 1.25 0
Cholate Source, % by weight 0.5 0
Related diets TD.09237?15% milk fat, 1% cholesterol
TD.88051?Hybrid version		 TD.94149?MCD control diet

Diets inducing obesity, metabolic syndrome and mild NAFLD/NASH

Western or fast food style diets fed to induce NASH with metabolic syndrome contain 40 – 45% kcal from milkfat (a fat source high in palmitate) with added cholesterol (0.15 – 2%) and are high in sucrose (>30%). Dietary palmitate and cholesterol have both previously been associated with the progression from simple steatosis to NASH.

Examples:

  • TD.88137?? ? ? Adjusted Calories Diet (42% from fat)
  • TD.96121?? ? ? 21% MF, 1.25% Chol. Diet
  • TD.120528? ? ?42% Kcal/Fat Diet (Incr. Sucrose, 1.25% Chol.)

Research use:

These diets can induce obesity, metabolic syndrome, and simple steatosis within nine weeks of feeding. Increased hepatic inflammation has been observed after 12 weeks of feeding. NASH typically requires longer feeding with fibrosis developing within nine months and late stage fibrosis including hepatic ballooning occurring after 14 – 20 months of feeding. Increasing dietary sucrose (~41%) and cholesterol (~1.25%) accelerates the NASH phenotype with steatosis, inflammation and hepatocyte ballooning observed within 12 weeks. In addition to feeding a high fat diet, providing a glucose/fructose mixture in the drinking water may further promote NASH development.

Select References:

Charlton, M., et al., Fast food diet mouse: novel small animal model of NASH with ballooning, progressive fibrosis, and high physiological fidelity to the human condition. Am J Physiol Gastrointest Liver Physiol, 2011. 301(5): p. G825-34.?http://www.ncbi.nlm.nih.gov/pubmed/21836057

Gores, G., Charlton M, Krishnan A, Viker K, Sanderson S, Cazanave S, McConico A, Masuoko H. Am J Physiol Gastrointest Liver Physiol, 2015. 308: p. G159.?http://ajpgi.physiology.org/content/308/2/G159

Li, Z.Z., et al., Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem, 2009. 284(9): p. 5637-44.?http://www.ncbi.nlm.nih.gov/pubmed/19119140

Ioannou, G.N., et al., Hepatic cholesterol crystals and crown-like structures distinguish NASH from simple steatosis. J Lipid Res, 2009. 54(5): p. 1326-34.?http://www.ncbi.nlm.nih.gov/pubmed/23417738

Alkhouri, N., et al., Adipocyte apoptosis, a link between obesity, insulin resistance, and hepatic steatosis. J Biol Chem, 2010. 285(5): p. 3428-38.?http://www.ncbi.nlm.nih.gov/pubmed/19940134

Dixon, L.J., et al., Caspase-1 as a central regulator of high fat diet-induced non-alcoholic steatohepatitis. PLoS One, 2013. 8(2): p. e56100.?http://www.ncbi.nlm.nih.gov/pubmed/23409132

DeLeve, L.D., et al., Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol, 2008. 173(4): p. 993-1001.?http://www.ncbi.nlm.nih.gov/pubmed/18772330

VanSaun, M.N., et al., High fat diet induced hepatic steatosis establishes a permissive microenvironment for colorectal metastases and promotes primary dysplasia in a murine model. Am J Pathol, 2009. 175(1): p. 355-64.?http://www.ncbi.nlm.nih.gov/pubmed/19541928

Asgharpour, A., et al., A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer. J Hepatol, 2016. 65(3): p. 579-88.?http://www.ncbi.nlm.nih.gov/pubmed/27261415

Tetri, L.H., et al., Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol, 2008. 295(5): p. G987-95.?http://www.ncbi.nlm.nih.gov/pubmed/18772365

Tsuchida, T., et al., A simple diet-and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer. Journal of hepatology, 2018. 69(2):385-395.?https://www.ncbi.nlm.nih.gov/pubmed/29572095

The American Lifestyle-Induced Obesity Syndrome (ALIOS) model involves feeding the “American fast food” diet high in trans-fats and sugar. Dietary trans-fats from hydrogenated vegetable shortening (HVO) are associated with increased insulin resistance and hepatic inflammation in rodent NASH models. In addition to diet, a glucose/fructose solution is added to the drinking water and sedentary behavior promoted by removing the overhead cage feeders in this model.

Examples:

  • TD.06303?? ? ??22% HVO Diet
  • TD.120330?? ??22% HVO + 0.2% Cholesterol Diet
  • TD.130885?? ??ALIOS with Added Sugar

Research use:

The ALIOS model develops obesity with insulin resistance, elevated ALT levels, and steatosis within 16 weeks. Increased inflammation and early development of fibrosis have been observed at 6 months. Severe steatosis with fibrosis and inflammation develops within 12 months of feeding with 50% of the mice reportedly developing hepatic neoplasms. Adding cholesterol (0.2%) to the American Fast Food diet may accelerate NASH phenotype development.

Select References:

Koppe, S.W., et al., Trans fat feeding results in higher serum alanine aminotransferase and increased insulin resistance compared with a standard murine high-fat diet. Am J Physiol Gastrointest Liver Physiol, 2009. 297(2): p. G378-84.?http://www.ncbi.nlm.nih.gov/pubmed/19541924

Tetri, L.H., et al., Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent. Am J Physiol Gastrointest Liver Physiol, 2008. 295(5): p. G987-95.?http://www.ncbi.nlm.nih.gov/pubmed/18772365

Mells, J.E., et al., Glp-1 analog, liraglutide, ameliorates hepatic steatosis and cardiac hypertrophy in C57BL/6J mice fed a Western diet. Am J Physiol Gastrointest Liver Physiol, 2012. 302(2): p. G225-35.?http://www.ncbi.nlm.nih.gov/pubmed/22038829

Dowman, J.K, et al., Development of hepatocellular carcinoma in a murine model of nonalcoholic steatohepatitis induced by use of a high-fat/fructose diet and sedentary lifestyle. Am J Pathol, 2014. 184(5):1550-1561.?https://www.ncbi.nlm.nih.gov/pubmed/24650559?

Mells, J.E., et al., Saturated fat and cholesterol are critical to inducing murine metabolic syndrome with robust nonalcoholic steatohepatitis. J Nutr Biochem, 2014. 26(3): p. 285-92.?http://www.ncbi.nlm.nih.gov/pubmed/25577467

The Fructose, Palmitate, Cholesterol and Trans-Fat (FPC) diet is a recent NASH diet that includes Western and ALIOS model diets to achieve both metabolic and hepatic NASH features within an accelerated time frame. Key features of the FPC diet include 1) a lower Met content than typical rodent diets by decreasing total protein without supplementing sulfur amino acids; 2) choline supplementation is lower than typical but is not considered deficient; 3) high in sucrose (~34% by weight); 4) 1.25% cholesterol; 5) 52% kcal from fat with fat sources including milkfat fat, palmitic acid and hydrogenated vegetable shortening to provide trans-fats. Like the ALIOS model, the FPC model also provides a glucose/fructose solution to the drinking water.

Examples:

  • TD.160785?? ??52 kcal/Fat Diet (C16:0, HVO, AMF, Choline/Met)

Research use:

Male C57BL/6J mice fed the FPC diet and provided a glucose/fructose drinking solution developed insulin resistance and NAFLD with inflammation, hepatocyte death, and fibrosis within 16 weeks.

Select References:

Wang, X., et al., Hepatocyte TAZ/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis. Cell Metab, 2016. 24(6): p. 848-62.?https://www.ncbi.nlm.nih.gov/pubmed/28068223??

Zhu, C., et al., Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis. Sci Transl Med, 2018. 10(468).?https://www.ncbi.nlm.nih.gov/pubmed/30463916

Common diets to induce obesity (DIO) can be fed to induce uncomplicated NAFLD. These high fat diets typically contain 40–60% kcal from fat without supplemented cholesterol or cholate. Simple sugars such as sucrose or fructose can also be supplemented via diet or water to progress the fatty liver phenotype. Diets can be in pellet or powder/dough form depending on the formula. Some models require limited physical activity and in those cases diets can be fed inside the cage. For more information see our?Diet Induced Obesity?page.

Examples:

  • TD.08811?? ? ??45%kcal Fat Diet (21% MF, 2% SBO)
  • TD.06414?? ? ??Adjusted Calories Diet (60/Fat)

Research use:

In susceptible rodent models, high fat diets are commonly used to induce NAFLD with obesity and insulin resistance common metabolic features associated with NASH in humans. However, the degree of NASH pathology (steatosis, inflammation, and fibrosis) is limited or mild and varies depending on the animal model, length of feeding, and dietary components.

Diets to induce severe hepatic NAFLD/NASH without obesity or metabolic

COLLAPSE ALL TABS

Originally formulated to induce mild atherosclerosis in wild-type rodents, high fat diets containing added cholesterol (1 – 1.25%) and cholate (0.5% as sodium cholate or cholic acid) have also been useful in inducing NASH. This diet option includes purified “Western” style diets with increased cholesterol and cholate and also hybrid diets. Hybrid diets were originally developed by Beverly Paigen and colleagues by mixing a natural ingredient mouse diet in a 3:1 ratio with a concentrated purified diet (containing 5% cholesterol and 2% sodium cholate) resulting in a diet containing ~15.8% fat, 1.25% cholesterol, and 0.5% sodium cholate. Although a less refined approach, the hybrid diet is associated with increased gallstone formation and liver damage as compared to similar purified diets.

Examples:

  • TD.02028?? ? ??Atherogenic Rodent Diet
  • TD.88051?? ? ??Cocoa Butter Diet and Purina Mouse Chow
  • TD.09237?? ? ??15% AMF Diet (1% Chol, 0.5% NaChol)

Research use:

Atherogenic diets are able to induce varied degrees of NASH with increased hepatic inflammation with early fibrosis observed after ten weeks of feeding. However, the metabolic profile typical in human NASH (obesity with insulin resistance) is not recapitulated in this model with animals typically maintaining similar body weights as control fed groups without the development of metabolic syndrome.

Select References:

Nishina, P.M., J. Verstuyft, and B. Paigen, Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J Lipid Res, 1990. 31(5): p. 859-69.?http://www.ncbi.nlm.nih.gov/pubmed/2380634

Kamari, Y., et al., Lack of interleukin-1alpha or interleukin-1beta inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice. J Hepatol, 2011. 55(5): p. 1086-94.?http://www.ncbi.nlm.nih.gov/pubmed/21354232

Kim, D.G., et al., Non-alcoholic fatty liver disease induces signs of Alzheimer’s disease (AD) in wild-type mice and accelerates pathological signs of AD in an AD model. J Neuroinflammation, 2016. 13: p. 1.?http://www.ncbi.nlm.nih.gov/pubmed/26728181

Madrigal-Perez, V.M., et al., Preclinical analysis of nonsteroidal anti-inflammatory drug usefulness for the simultaneous prevention of steatohepatitis, atherosclerosis and hyperlipidemia. Int J Clin Exp Med, 2015. 8(12): p. 22477-83.?http://www.ncbi.nlm.nih.gov/pubmed/26885230

Savransky, V., et al., Chronic intermittent hypoxia causes hepatitis in a mouse model of diet-induced fatty liver. Am J Physiol Gastrointest Liver Physiol, 2007. 293(4): p. G871-7.?http://www.ncbi.nlm.nih.gov/pubmed/17690174

Methionine and choline deficient (MCD) diets are amino acid defined rodent diets deficient in methionine and choline, high in sucrose (>40% by weight) with ~10% corn oil by weight. Methionine and choline deficiency decreases fat oxidation and export of fat from the liver. Dietary sucrose is necessary for hepatic lipid accumulation and oxidation. The polyunsaturated fat in corn oil promotes hepatic lipid oxidation.

Example:

  • TD.90262?? ? ??Methionine/Choline Deficient Diet

Control:

  • TD.94149?? ? ??Amino Acid Control Diet

Research use:

Steatosis, increased serum alanine aminotransferase (ALT), inflammation, and hepatic fat oxidation has been observed within three weeks of feeding the MCD diet with fibrosis development after six weeks. This dietary model does not produce metabolic syndrome (an aspect of NASH in human models) and progressive weight loss (up to 40%) is associated with the MCD diet feeding.

蛋氨酸/膽堿缺乏癥(MCD)日糧
蛋氨酸和膽堿缺乏(MCD)飼料是一種氨基酸定義的嚙齒動物飼料，缺乏蛋氨酸和膽堿，蔗糖含量高(體重>40%)，玉米油含量約10%。蛋氨酸和膽堿缺乏減少脂肪氧化和從肝臟輸出脂肪。日糧蔗糖對肝臟脂質的積累和氧化是必需的。玉米油中的多不飽和脂肪促進肝臟脂質氧化。

例子：TD.90262 蛋氨酸/膽堿缺乏癥飲食
管制：TD.94149 氨基酸控制飲食

研究用途：

觀察到脂肪變性、血清丙氨酸轉氨酶(ALT)升高、炎癥和肝脂肪氧化反應。這種飲食模式不會產生代謝綜合癥(在人類模型中是NASH的一個方面)和累進性減肥(高達40%)與MCD飲食喂養(yǎng)有關。

Select References:

Pickens, M.K., et al., Dietary sucrose is essential to the development of liver injury in the MCD model of steatohepatitis. J Lipid Res, 2009. 50(10):2072-82.??http://www.ncbi.nlm.nih.gov/pubmed/19295183

Li, Z.Z., et al., Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. J Biol Chem, 2009. 284(9): p. 5637-44.?http://www.ncbi.nlm.nih.gov/pubmed/19119140

Lee, G.S., et al., Polyunsaturated fat in the methionine-choline-deficient diet influences hepatic inflammation but not hepatocellular injury. J Lipid Res, 2007. 48(8): p. 1885-96.?http://www.ncbi.nlm.nih.gov/pubmed/17526933

Vetelainen, R., A. van Vliet, and T.M. van Gulik, Essential pathogenic and metabolic differences in steatosis induced by choline or methione-choline deficient diets in a rat model. J Gastroenterol Hepatol, 2007. 22(9): p. 1526-33.?http://www.ncbi.nlm.nih.gov/pubmed/17716355

Leclercq, I.A., et al., Intrahepatic insulin resistance in a murine model of steatohepatitis: effect of PPARgamma agonist pioglitazone. Lab Invest, 2007. 87(1): p. 56-65.?http://www.ncbi.nlm.nih.gov/pubmed/17075577

Kashireddy, P.R. and M.S. Rao, Sex differences in choline-deficient diet-induced steatohepatitis in mice. Exp Biol Med (Maywood), 2004. 229(2): p. 158-62.?http://www.ncbi.nlm.nih.gov/pubmed/14734794

Dixon, L.J., et al., Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. Lab Invest, 2012. 92(5): p. 713-23.?http://www.ncbi.nlm.nih.gov/pubmed/22411067

Dietary models of NAFLD/NASH continue to evolve with the goal of more accurately recapitulating both the metabolic and hepatic symptoms of human disease. Commonly researchers are studying the synergistic effects of various NASH dietary features to accelerate progression of the model and severity of liver disease.

A Teklad nutritionist can work with you to formulate new diets in order to investigate novel dietary models of NAFLD/NASH.

The choice of control diet is dependent on the specific research goal. Many researchers choose to compare their NAFLD/NASH diet-fed animals to animals fed a natural ingredient, grain-based diet (also referred to as standard diet or chow). These diets differ in the source and level of nutrients as well as in the presence of non-nutritive factors (such as phytates or phytoestrogens).

Depending on what your main comparisons are, it may be suitable to have a grain-based diet as your control/reference group. However, making such comparisons limits inferences to dietary patterns versus a specific dietary component. In some cases, such as those studies feeding amino acid defined diets like the MCD model, a matched control diet is recommended given the very different formulations and protein sources of grain-based diets.

When making inferences about specific nutrients within the diet an ingredient matched, low fat control diet may be necessary. There are many options with different levels and types of fat in addition to different types of carbohydrate ranging from sucrose (highly refined and digestible) to corn starch (refined, but more complex) to resistant starch (refined, but not fully digestible).

A very basic purified control diet would be AIN-93M?TD.94048?or AIN-93G?TD.94045. AIN-93 diets have a moderate amount of sucrose at ~10% with fat from soybean oil providing a healthy fatty acid profile.

Contact a nutritionist?for an additional information and control diet recommendations.

對照日糧
控制飲食的選擇取決于具體的研究目標。許多研究人員選擇比較他們的NAFLD/納什飲食喂養(yǎng)的動物和喂養(yǎng)一種天然成分的動物，谷物為基礎的飲食(也稱為標準飲食或周食)。這些飲食在營養(yǎng)來源和水平以及非營養(yǎng)因素(如植酸鹽或植物雌激素)存在的情況下存在差異。

根據(jù)您的主要比較，它可能適合作為您的對照/參考組谷物基礎的飲食。然而，這樣的比較限制了對飲食模式和特定飲食成分的推斷。在某些情況下，如那些研究喂食氨基酸定義的飲食，如mcd模型，建議一個匹配的對照飲食，考慮到非常不同的配方和蛋白質來源的谷物為基礎的飲食。

當對飲食中的特定營養(yǎng)成分做出相應的推斷時，低脂控制飲食可能是必要的。除了不同類型的碳水化合物外，還有許多不同水平和類型的脂肪，從蔗糖(高精制和可消化)到玉米淀粉(精制，但更復雜)，再到抗性淀粉(精制，但不能完全消化)。

一種非常基本的純正控制飲食將是-9300萬。TD.94048或者是93g TD.94045。AIN-93日糧中含有適量的蔗糖~10%，大豆油中的脂肪提供了健康的脂肪酸譜。

Need more information? A Teklad nutritionist will work with you to determine if existing diets will meet your needs or formulate new diets to help you investigate novel dietary models of NAFLD/NASH.?Contact us?for a diet consultation.

定制國產飼料，TD88137-Hayek模型飼料-Harlan飼料

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TD88137（Hayek模型飼料）是西方飲食飼料中使用比較廣泛的一種，在較多文章中都有體現(xiàn)，被廣泛使用在多種模型的建立上，比如，肥胖模型、高血脂模型、高膽固醇血癥模型、胰島素抵抗模型、II型糖尿病模型、代謝綜合癥模型、脂肪肝模型，動脈粥樣硬化模型等。

上海金畔生物科技有限公司定制TD88137（Hayek模型飼料）飼料，性能穩(wěn)定，收到眾多實驗室好評。歡迎來電咨詢，量多優(yōu)惠，貨期1-2周。

Harlan Teklad TD.08485 Low Fat Control Diet低脂飼料

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Harlan Teklad TD.08485 Low Fat Control Diet低脂飼料

Harlan Teklad代理，Harlan?飼料代理，歡迎訪問Harlan Teklad官網或者咨詢我們獲取更多相關產品信息。

Control diets can be designed in several ways, depending on what features the researcher wants to modify relative to the high-fat diet. These are just a few examples.

Commonly-used diet-induced obesity (DIO) Teklad rodent diets with 40-45% of calories from fat

Formula g/Kg
Casein 195
DL-Methionine 3
Sucrose 120
Corn Starch 432.99
Maltodextrin 100
Anhydrous Milkfat 37.2
Soybean Oil 12.8
Cellulose 50
Mineral Mix, AIN-76 (170915) 35
Calcium Carbonate 4
Vitamin Mix, Teklad (40060) 10
Ethoxyquin, antioxidant 0.01

Footnote

This is modified from TD.88137 to reduce fat, reduce sucrose, and remove cholesterol.

elected Nutrient Information1

 

% by weight % kcal from
Protein 17.3 19.1
Carbohydrate 61.3 67.9
Fat 5.2 13.0
Kcal/g 3.6
  • Values are calculated from ingredient analysis or manufacturer data

Key Features

  • Purified Diet
  • Modification of TD.88137
  • Low Fat & No Added Cholesterol
  • Reduced Sucrose

Key Planning Information

  • Products are made fresh to order
  • Store product at 4°C or lower
  • Use within 6 months (applicable to most diets)
  • Box labeled with product name, manufacturing date, and lot number
  • Replace diet at minimum once per week

More frequent replacement may be advised

  • Lead time:
  • 2 weeks non-irradiated
  • 4 weeks irradiated

 

Harlan TD.00158 維生素A缺乏飲食 Vitamin A Deficient Diet 使用說明

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Harlan TD.00158 維生素A缺乏飲食 Vitamin A Deficient Diet

貨號：TD.00158

英文名稱：Vitamin A Deficient Diet

Formula g/Kg
Casein,”iamin-Freet”Test 200
L-Cystine 3
Com?Starch 397.486
Maltodextrin 132
Sucrose 109.755
Soybean?Oil 70
Cellulose 50
Mineral?Mix,?AIN-93G-MX?(94046) 35
Choline?Bitartrate 2.5
TBHQ,?antioxidant 0.014
Niacin 0.03
Calcium?Pantothenate 0.016
Pyridoxine?HCI 0.007
Thiamin?(81%) 0.006
Riboflavin 0.006
Folic?Acid 0.002
Biotin 0.0002
Vitamin?B.2?(0.1%?in?mannitol) 0.025
Vitamin?E?DL-alpha?tocooheryl?acetate?(500?IU/g) 0.15
Vitamin?D3?cholecalciferol?(500,000?lU/g) 0.002
Vitamin?K1.?phyloquinone 0.0008

Footnote
This modification of diet AIN-93G (TD 94045) omits vitamin A palmitate and
substitutes alcohol-extracted casein for regular casein. Diet should contain
less than 20 IU vitamin AVkg diet.

Selected Nutrient Information

%?by?weight %?kcal?from
Protein 18.3 19.4
Carbohydrate 60.1 63.8
Fat 7 16.7
Kcalg 3.8

Key Features
+ Purified Diet
+ Vitamin A
+ VFT Casein
+ AIN-93G Modification

Key Planning Information
+ Products are made fresh to order
+ Store product at 4°C or lower? ?將產品存放在4°C或更低的溫度下

+Use within 6 months (applicable to most diets)
+ Box labeled with product name,
manufacturing date, and lot number
+ Replace diet at minimum once per week
More frequent replacement may be advised

+ Lead time:
2 weeks non-irradiated
4 weeks irradiated

Product Specific Information
1/2”Peilet of Powder (free flowing)? 1/2”粉餅（自由流動）
+ Minimum order 3 Kg
+ Irradiation not advisea
Contact a nutntionist for recommendations

Harlan Teklad 動物飼料 Vitamin A Diet(25,000)成分表

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Harlan Teklad 動物飼料 Vitamin A Diet(25,000)成分表

Harlan Teklad動物飼料
Harlan代理–上海金畔生物科技有限公司
歡迎新老客戶訪問Harlan官網或者咨詢中國代理商上海金畔生物獲取更多詳細資料。

Formula g/Kg
Casein,?“Vitamin-Free”Test 200
L-Cystine 3
Com?Starch 397.486
Maltodextrin 132
Sucrose 109.705
Soybean Oil 70
Cellulose 50
Mineral?Mix,?AIN-93G-MX?(94046) 35
Choline?Bitartrate 2.5
TBHQ,?antioxidant 0.014
Niacin 0.03
Calcium?Pantothenate 0.016
Pyridoxine?HCI 0.007
Thiamin?(81%) 0.006
Riboflavin 0.006
Folic?Acid 0.002
Biotin 0.0002
Vitamin?B12?(0.1%?in?manitol) 0.025
Vitamin?E?DL?alpha?tocopheryl?acetate?(500?IU/g) 0.15
Vitamin?D3.?cholecalciferol?(500,000?IU/g) 0.002
Vitamin?K1,?phylloquinone 0.0008
Vitamin?A?Acetate?(500,000?IU/g) 0.05

Foothote

This modification of diet AIN-93G (TD.94045) replaces vitamin A palmitate with
tamin A acetate and increases the total concentration to approximately 25,000
/kg. Alcohol-extracted casein is substituted for regular casein.

Selected Nutrient Information

%?by?weight %?kcal?from
Protein 18.3 19.4
Carbohydrate 60.1 63.8
Fat 7 16.7
Kcal/g 3.8

Values are calculated from ingredient analysis or manufacturer data

Key Features

+ Purifield? ?Diet
+Vitamin A
+AlN 93G Modification
+ Rodent

Key Planning Information

+ Product are made Fresh fo order
+ store product at 4° C or IoWer
+ Use within 6 months(appIicable to most diets)
+ Box Labeled with product name
manufaGturing date,and Iot number
+ Replace diet at nninimunη once per weekation

Harlan動物飼料 TD.01306 Rodent Diet (2018, 625 Doxycycline) 成分表

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Harlan動物飼料 TD.01306 Rodent Diet (2018, 625 Doxycycline) 成分表

Harlan Teklad動物飼料
Harlan代理–上海金畔生物科技有限公司
歡迎新老客戶訪問Harlan官網或者咨詢中國代理商上海金畔生物獲取更多詳細資料。

嚙齒動物飼料（2018，625強力霉素）

Formula g/Kg
2018, Teklad Global 18% Protein Rodent Diet 999.375
Doxycycline Hyclate 0.625

Footnote? ?Harlan動物飼料 TD.01306 Rodent Diet (2018, 625 Doxycycline) 使用說明

This diet was designed to deliver a daily dose of 2-3 mg of doxycycline based on consumption of 4-5 g/d by a mouse. Doxycycline hyclate contains approximately 87% doxycycline.

這種飲食被設計為以小鼠每天4-5 g / d的消耗量提供2-3 mg強力霉素的日劑量。 鹽酸多西環(huán)素含有約87％的多西環(huán)素。

Selected Nutrient Information

  % by weight % kcal from
Protein 18.2 22.9
Carbohydrate2 48.0 60.5
Fat 5.8 16.6
Kcal/g 3.2  
  • Values are calculated from ingredient analysis or manufacturer data
  • Estimated digestible carbohydrate

Key Features

  • Standard Diet Base
  • Doxycycline
  • Gene Induction
  • 2018

Key Planning Information

  • Products are made fresh to order
  • Store product at 4°C or lower
  • Use within 6 months (applicable to most diets)
  • Box labeled with product name, manufacturing date, and lot number
  • Replace diet at minimum once per week

More frequent replacement may be advised

  • Lead time:
  • 2 weeks non-irradiated
  • 4 weeks irradiated

Product Specific Information

  • 1/2″ Pellet or Powder (free flowing)
  • Minimum order 3 Kg
  • Irradiation available upon request