葡聚糖硫酸鈉（Dextran Sulfate Sodium Salt,DSS）是一種聚陰離子衍生物，是目前腸炎造模研究領(lǐng)域金標(biāo)準(zhǔn)。MP Biomedicals公司生產(chǎn)的獨(dú)特的葡聚糖硫酸鈉是同行科學(xué)評(píng)議刊物里應(yīng)用最多的一種產(chǎn)品，迄今為止，有超過(guò)8000篇科學(xué)文獻(xiàn)引用，有效性得到了業(yè)界廣泛認(rèn)可。
Application Notes
葡聚糖硫酸鈉 (DSS)是最常見(jiàn)、最有效的誘導(dǎo)潰瘍性結(jié)腸炎的藥物之一。DSS結(jié)腸炎模型也被廣泛應(yīng)用于研究結(jié)腸癌的發(fā)展與結(jié)腸炎癥的關(guān)系，例如對(duì)長(zhǎng)期潰瘍性結(jié)腸炎的研究。我公司可提供結(jié)腸炎模型創(chuàng)建試劑的金標(biāo)準(zhǔn)-結(jié)腸炎級(jí)葡聚糖硫酸鈉(分子量36,000-50,000) 和結(jié)腸致癌物偶氮甲烷 (AOM)因其高效性而成為科學(xué)文獻(xiàn)中應(yīng)用最廣泛的DSS產(chǎn)品之一。在過(guò)去的15年中，超過(guò)8000份科研文獻(xiàn)引用了我公司的DSS產(chǎn)品。
Usage Statement
Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Acute/ Chronic Ulcerative Colitis Model Induction, Chronic Colitis Associated Colon Cancer Model Induction
| SKU | 02160110-CF |
| Alternate Names | DSS, Dextran Sodium Sulfate |
| Application Notes | 葡聚糖硫酸鈉 (DSS)是最常見(jiàn)、最有效的誘導(dǎo)潰瘍性結(jié)腸炎的藥物之一。DSS結(jié)腸炎模型也被廣泛應(yīng)用于研究結(jié)腸癌的發(fā)展與結(jié)腸炎癥的關(guān)系，例如對(duì)長(zhǎng)期潰瘍性結(jié)腸炎的研究。我公司可提供結(jié)腸炎模型創(chuàng)建試劑的金標(biāo)準(zhǔn)-結(jié)腸炎級(jí)葡聚糖硫酸鈉(分子量36,000-50,000) 和結(jié)腸致癌物偶氮甲烷 (AOM)因其高效性而成為科學(xué)文獻(xiàn)中應(yīng)用最廣泛的DSS產(chǎn)品之一。在過(guò)去的15年中，超過(guò)8000份科研文獻(xiàn)引用了我公司的DSS產(chǎn)品。 |
| Base Catalog Number | 160110 |
| Boiling Point | 310 ° C |
| CAS # | 9011-18-1 |
| Grade | Colitis Grade |
| Melting Point | 92 ° C |
| Molecular Weight | 36,000 – 50,000 Da |
| Personal Protective Equipment | Eyeshields, Gloves, respirator filter |
| pH | (1% aqueous solution) 5-7.11 |
| References | Kinchen, J. Structural Remodeling of the Human Colonic Mesenchyme in Inflammatory Bowel Disease. Cell. 2018, 175, 372-386.
Mahalhal , A. Oral iron exacerbates colitis and influences the intestinal microbiome, PLOS ONE. 2018, 13, e0202460.
Dokoshi, T. Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin. JCI Insight. 2018, 3, e12307.
Zhu, H. RNA virus receptor Rig-I monitors gut microbiota and inhibits colitis-associated colorectal cancer. J. Exp. Clin. Cancer Res. 2017, 36, 2.
Monticelli, L. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin–EGFR interactions. PNAS. 2015, 112, 10762-10767. |
| RTECS Number | HH9290000 |
| Solubility | 100 mg/mL (decreases with increasing of MW) |
| Usage Statement | Unless specified otherwise, MP Biomedical’s products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| Vapor Pressure | 2.6 x 10-4 mm Hg at 25 ° C (Estimated) |
